TY - CONF

T1 - Fast, compact and label-free electrical detection of live and dead single cells

AU - Ning, Y.

AU - Multari, C.R.

AU - Luo, X.

AU - Merla, C.

AU - Palego, C.

AU - Cheng, X.

AU - Hwang, J.C.

PY - 2013/12/9

Y1 - 2013/12/9

N2 - Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.

AB - Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.

U2 - 10.1109/IMWS-BIO.2013.6756250

DO - 10.1109/IMWS-BIO.2013.6756250

M3 - Paper

T2 - Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore

Y2 - 3 January 0001

ER -