Fast, compact and label-free electrical detection of live and dead single cells
Research output: Contribution to conference › Paper
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2013. Paper presented at Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore.
Research output: Contribution to conference › Paper
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T1 - Fast, compact and label-free electrical detection of live and dead single cells
AU - Ning, Y.
AU - Multari, C.R.
AU - Luo, X.
AU - Merla, C.
AU - Palego, C.
AU - Cheng, X.
AU - Hwang, J.C.
PY - 2013/12/9
Y1 - 2013/12/9
N2 - Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.
AB - Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.
U2 - 10.1109/IMWS-BIO.2013.6756250
DO - 10.1109/IMWS-BIO.2013.6756250
M3 - Paper
T2 - Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore
Y2 - 3 January 0001
ER -