TY - JOUR

T1 - Identification of youth at clinical high-risk for psychosis: A community-based study from India.

AU - Tikka, Sai Krishna

AU - Malathesh, Barikar C.

AU - Spoorthy, Mamidipalli Sai

AU - Kusneniwar, Govindrao N.

AU - Agarwal, Neeraj

AU - D Avossa, Giovanni

AU - Katshu, Mohammad Zia Ul Haq

PY - 2024/5/28

Y1 - 2024/5/28

N2 - Aim: A two-stage process, wherein self-report screening precedes the structuredinterview, is suggested for identifying individuals at clinical high-risk for psychosis (CHR-P) in community samples. Aim of this study was to screen a community youth sample from India for CHR-P using the two-stage method. Specific objectives were to assess concordant validity of the self-report measure and predictive validity of the two-stage method.Methods: Based on probability sampling, 2025 youth aged 15–24 years wererecruited from one rural and one urban area of Telangana, a Telugu-speaking state in India. Telugu version of the PRIME Screen-Revised (PS-R) and structured interview for psychosis-risk syndromes (SIPS) were used. CHR-P positive and negative cohorts were followed-up for transition to psychosis at 3-monthly intervals.Results: One hundred ten individuals screened positive on PS-R. SIPS conducted on 67 out of 110 individuals confirmed 62 (92.54%) to be CHR-P positive. PS-R showed 98.41% sensitivity and 90.74% specificity. Among CHR-P positive, three participants transitioned to psychosis in 15 months. The hazard ratio for psychosis transition was 11.4.Conclusions: Screening accuracy of PS-R in the community youth sample in Telangana is optimum. The hazard ratio for psychosis transition in the community identified CHR-P indicates good predictive validity for the two-stage method.

AB - Aim: A two-stage process, wherein self-report screening precedes the structuredinterview, is suggested for identifying individuals at clinical high-risk for psychosis (CHR-P) in community samples. Aim of this study was to screen a community youth sample from India for CHR-P using the two-stage method. Specific objectives were to assess concordant validity of the self-report measure and predictive validity of the two-stage method.Methods: Based on probability sampling, 2025 youth aged 15–24 years wererecruited from one rural and one urban area of Telangana, a Telugu-speaking state in India. Telugu version of the PRIME Screen-Revised (PS-R) and structured interview for psychosis-risk syndromes (SIPS) were used. CHR-P positive and negative cohorts were followed-up for transition to psychosis at 3-monthly intervals.Results: One hundred ten individuals screened positive on PS-R. SIPS conducted on 67 out of 110 individuals confirmed 62 (92.54%) to be CHR-P positive. PS-R showed 98.41% sensitivity and 90.74% specificity. Among CHR-P positive, three participants transitioned to psychosis in 15 months. The hazard ratio for psychosis transition was 11.4.Conclusions: Screening accuracy of PS-R in the community youth sample in Telangana is optimum. The hazard ratio for psychosis transition in the community identified CHR-P indicates good predictive validity for the two-stage method.

KW - psychosis

KW - Epidemiology

U2 - 10.1111/eip.13581

DO - 10.1111/eip.13581

M3 - Article

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

SN - 1751-7885

ER -