Identification of youth at clinical high-risk for psychosis: A community-based study from India.
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In: Early Intervention in Psychiatry, 28.05.2024.
Research output: Contribution to journal › Article › peer-review
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T1 - Identification of youth at clinical high-risk for psychosis: A community-based study from India.
AU - Tikka, Sai Krishna
AU - Malathesh, Barikar C.
AU - Spoorthy, Mamidipalli Sai
AU - Kusneniwar, Govindrao N.
AU - Agarwal, Neeraj
AU - D Avossa, Giovanni
AU - Katshu, Mohammad Zia Ul Haq
PY - 2024/5/28
Y1 - 2024/5/28
N2 - Aim: A two-stage process, wherein self-report screening precedes the structuredinterview, is suggested for identifying individuals at clinical high-risk for psychosis (CHR-P) in community samples. Aim of this study was to screen a community youth sample from India for CHR-P using the two-stage method. Specific objectives were to assess concordant validity of the self-report measure and predictive validity of the two-stage method.Methods: Based on probability sampling, 2025 youth aged 15–24 years wererecruited from one rural and one urban area of Telangana, a Telugu-speaking state in India. Telugu version of the PRIME Screen-Revised (PS-R) and structured interview for psychosis-risk syndromes (SIPS) were used. CHR-P positive and negative cohorts were followed-up for transition to psychosis at 3-monthly intervals.Results: One hundred ten individuals screened positive on PS-R. SIPS conducted on 67 out of 110 individuals confirmed 62 (92.54%) to be CHR-P positive. PS-R showed 98.41% sensitivity and 90.74% specificity. Among CHR-P positive, three participants transitioned to psychosis in 15 months. The hazard ratio for psychosis transition was 11.4.Conclusions: Screening accuracy of PS-R in the community youth sample in Telangana is optimum. The hazard ratio for psychosis transition in the community identified CHR-P indicates good predictive validity for the two-stage method.
AB - Aim: A two-stage process, wherein self-report screening precedes the structuredinterview, is suggested for identifying individuals at clinical high-risk for psychosis (CHR-P) in community samples. Aim of this study was to screen a community youth sample from India for CHR-P using the two-stage method. Specific objectives were to assess concordant validity of the self-report measure and predictive validity of the two-stage method.Methods: Based on probability sampling, 2025 youth aged 15–24 years wererecruited from one rural and one urban area of Telangana, a Telugu-speaking state in India. Telugu version of the PRIME Screen-Revised (PS-R) and structured interview for psychosis-risk syndromes (SIPS) were used. CHR-P positive and negative cohorts were followed-up for transition to psychosis at 3-monthly intervals.Results: One hundred ten individuals screened positive on PS-R. SIPS conducted on 67 out of 110 individuals confirmed 62 (92.54%) to be CHR-P positive. PS-R showed 98.41% sensitivity and 90.74% specificity. Among CHR-P positive, three participants transitioned to psychosis in 15 months. The hazard ratio for psychosis transition was 11.4.Conclusions: Screening accuracy of PS-R in the community youth sample in Telangana is optimum. The hazard ratio for psychosis transition in the community identified CHR-P indicates good predictive validity for the two-stage method.
KW - psychosis
KW - Epidemiology
U2 - 10.1111/eip.13581
DO - 10.1111/eip.13581
M3 - Article
JO - Early Intervention in Psychiatry
JF - Early Intervention in Psychiatry
SN - 1751-7885
ER -