Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Chemistry and Physics of Lipids, Cyfrol 233, 104977, 11.2020.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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TY - JOUR
T1 - Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis
AU - Alhuwaymil, Zamzam S.
AU - Al-araj, Intisar Q.M.
AU - Dulayymi, Ahmad R. Al
AU - Jones, Alison
AU - Gates, Paul J.
AU - Valero-Guillén, Pedro L.
AU - Baird, Mark S.
AU - Dulayymi, Juma’a R. Al
PY - 2020/11
Y1 - 2020/11
N2 - Cells of Mycobacterium alvei are known to contain a unique set of mycolic acids with a (ω-1)-methoxy group; although the various enzymes in the biosynthesis of other types of mycolic acid have been widely studied, the biosynthetic route to this substituent is unclear. We now define the stereochemistry of the (ω-1)-methoxy fragment as R, and describe the synthesis of a major R-(ω-1)-methoxy-mycolic acid and its sugar esters, and of two natural M. alvei diene mycolic acids.
AB - Cells of Mycobacterium alvei are known to contain a unique set of mycolic acids with a (ω-1)-methoxy group; although the various enzymes in the biosynthesis of other types of mycolic acid have been widely studied, the biosynthetic route to this substituent is unclear. We now define the stereochemistry of the (ω-1)-methoxy fragment as R, and describe the synthesis of a major R-(ω-1)-methoxy-mycolic acid and its sugar esters, and of two natural M. alvei diene mycolic acids.
KW - Mycobacterium
KW - Alvei
KW - Mycolic acid
KW - (ω-1)-Methoxy
KW - Synthesis
U2 - 10.1016/j.chemphyslip.2020.104977
DO - 10.1016/j.chemphyslip.2020.104977
M3 - Article
VL - 233
JO - Chemistry and Physics of Lipids
JF - Chemistry and Physics of Lipids
SN - 0009-3084
M1 - 104977
ER -