On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD).

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On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD). / Feige, B.; Biscaldi, Monica; Saville, Christopher et al.
Yn: PLoS ONE, 02.10.2013, t. e69674.

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Feige, B, Biscaldi, M, Saville, C, Kluckert, C, Bender, S, Ebner-Priemer, U, Henighausen, K, Rauh, R, Fleischhaker, C & Klein, C 2013, 'On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD).', PLoS ONE, tt. e69674. https://doi.org/10.1371/journal.pone.0069674

APA

Feige, B., Biscaldi, M., Saville, C., Kluckert, C., Bender, S., Ebner-Priemer, U., Henighausen, K., Rauh, R., Fleischhaker, C., & Klein, C. (2013). On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD). PLoS ONE, e69674. https://doi.org/10.1371/journal.pone.0069674

CBE

Feige B, Biscaldi M, Saville C, Kluckert C, Bender S, Ebner-Priemer U, Henighausen K, Rauh R, Fleischhaker C, Klein C. 2013. On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD). PLoS ONE. e69674. https://doi.org/10.1371/journal.pone.0069674

MLA

VancouverVancouver

Feige B, Biscaldi M, Saville C, Kluckert C, Bender S, Ebner-Priemer U et al. On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD). PLoS ONE. 2013 Hyd 2;e69674. doi: 10.1371/journal.pone.0069674

Author

RIS

TY - JOUR

T1 - On the temporal characteristics of performance variability in attention deficit hyperactivity disorder (ADHD).

AU - Feige, B.

AU - Biscaldi, Monica

AU - Saville, Christopher

AU - Kluckert, C.

AU - Bender, Stephan

AU - Ebner-Priemer, Ulrich

AU - Henighausen, K.

AU - Rauh, R.

AU - Fleischhaker, C.

AU - Klein, Christoph

PY - 2013/10/2

Y1 - 2013/10/2

N2 - Increased intra-subject variability of reaction times (ISV-RT) is one of the most consistent findings in attention-deficit/hyperactivity disorder (ADHD). Although the nature of this phenomenon is still unclear, it has been hypothesised to reflect interference from the Default Mode Network (DMN). So far, ISV-RT has been operationally defined either as a frequency spectrum of the underlying RT time series, or as a measure of dispersion of the RT scores distribution. Here, we use a novel RT analysis framework to link these hitherto unconnected facets of ISV-RT by determining the sensitivity of different measures of RT dispersion to the frequency content of the underlying RT time series. N=27 patients with ADHD and N=26 healthy controls performed several visual N-back tasks. Different measures of RT dispersion were repeatedly modelled after individual frequency bands of the underlying RT time series had been either extracted or suppressed using frequency-domain filtering. We found that the intra-subject standard deviation of RT preserves the "1/f noise" characteristic typical of human RT data. Furthermore and most importantly, we found that the ex-Gaussian parameter τ is rather exclusively sensitive to frequencies below 0.025 Hz in the underlying RT time series and that the particularly slow RTs, which nourish τ, occur regularly as part of an quasi-periodic, ultra-slow RT fluctuation. Overall, our results are compatible with the idea that ISV-RT is modulated by an endogenous, slowly fluctuating process that may reflect DMN interference.

AB - Increased intra-subject variability of reaction times (ISV-RT) is one of the most consistent findings in attention-deficit/hyperactivity disorder (ADHD). Although the nature of this phenomenon is still unclear, it has been hypothesised to reflect interference from the Default Mode Network (DMN). So far, ISV-RT has been operationally defined either as a frequency spectrum of the underlying RT time series, or as a measure of dispersion of the RT scores distribution. Here, we use a novel RT analysis framework to link these hitherto unconnected facets of ISV-RT by determining the sensitivity of different measures of RT dispersion to the frequency content of the underlying RT time series. N=27 patients with ADHD and N=26 healthy controls performed several visual N-back tasks. Different measures of RT dispersion were repeatedly modelled after individual frequency bands of the underlying RT time series had been either extracted or suppressed using frequency-domain filtering. We found that the intra-subject standard deviation of RT preserves the "1/f noise" characteristic typical of human RT data. Furthermore and most importantly, we found that the ex-Gaussian parameter τ is rather exclusively sensitive to frequencies below 0.025 Hz in the underlying RT time series and that the particularly slow RTs, which nourish τ, occur regularly as part of an quasi-periodic, ultra-slow RT fluctuation. Overall, our results are compatible with the idea that ISV-RT is modulated by an endogenous, slowly fluctuating process that may reflect DMN interference.

U2 - 10.1371/journal.pone.0069674

DO - 10.1371/journal.pone.0069674

M3 - Article

SP - e69674

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

ER -