TY - JOUR

T1 - Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

AU - Fenton, Sally A.M.

AU - Sandoo, Aamer

AU - Metsios, George S

AU - Duda, J.L.

AU - Kitas, George D.

AU - Veldhuijzen van Zanten, Jet J. C. S.

PY - 2018/5

Y1 - 2018/5

N2 - BackgroundSedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.ObjectivesTo investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.MethodsSixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).ResultsRegressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = −3.25, p = .02, 95% CI [−6.07, −.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).ConclusionHabitual sedentary behaviour (sitting time) appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

AB - BackgroundSedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.ObjectivesTo investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.MethodsSixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).ResultsRegressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = −3.25, p = .02, 95% CI [−6.07, −.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).ConclusionHabitual sedentary behaviour (sitting time) appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

U2 - 10.1016/j.mvr.2018.01.005

DO - 10.1016/j.mvr.2018.01.005

M3 - Article

VL - 117

SP - 57

EP - 60

JO - Microvascular Research

JF - Microvascular Research

SN - 0026-2862

ER -