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Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

Research output: Contribution to journal › Article › peer-review

Standard Standard

Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. / Fenton, Sally A.M.; Sandoo, Aamer; Metsios, George S et al.
In: Microvascular Research, Vol. 117, 05.2018, p. 57-60.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Fenton, SAM, Sandoo, A, Metsios, GS, Duda, JL, Kitas, GD & Veldhuijzen van Zanten, JJCS 2018, 'Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis', Microvascular Research, vol. 117, pp. 57-60. https://doi.org/10.1016/j.mvr.2018.01.005

APA

Fenton, S. A. M., Sandoo, A., Metsios, G. S., Duda, J. L., Kitas, G. D., & Veldhuijzen van Zanten, J. J. C. S. (2018). Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. Microvascular Research, 117, 57-60. https://doi.org/10.1016/j.mvr.2018.01.005

CBE

Fenton SAM, Sandoo A, Metsios GS, Duda JL, Kitas GD, Veldhuijzen van Zanten JJCS. 2018. Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. Microvascular Research. 117:57-60. https://doi.org/10.1016/j.mvr.2018.01.005

MLA

Fenton, Sally A.M. et al. "Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis". Microvascular Research. 2018, 117. 57-60. https://doi.org/10.1016/j.mvr.2018.01.005

VancouverVancouver

Fenton SAM, Sandoo A, Metsios GS, Duda JL, Kitas GD, Veldhuijzen van Zanten JJCS. Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. Microvascular Research. 2018 May;117:57-60. Epub 2018 Feb 21. doi: 10.1016/j.mvr.2018.01.005

Author

Fenton, Sally A.M. ; Sandoo, Aamer ; Metsios, George S et al. / Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. In: Microvascular Research. 2018 ; Vol. 117. pp. 57-60.

RIS

TY - JOUR

T1 - Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

AU - Fenton, Sally A.M.

AU - Sandoo, Aamer

AU - Metsios, George S

AU - Duda, J.L.

AU - Kitas, George D.

AU - Veldhuijzen van Zanten, Jet J. C. S.

PY - 2018/5

Y1 - 2018/5

N2 - BackgroundSedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.ObjectivesTo investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.MethodsSixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).ResultsRegressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = −3.25, p = .02, 95% CI [−6.07, −.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).ConclusionHabitual sedentary behaviour (sitting time) appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

AB - BackgroundSedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.ObjectivesTo investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.MethodsSixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).ResultsRegressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = −3.25, p = .02, 95% CI [−6.07, −.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).ConclusionHabitual sedentary behaviour (sitting time) appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

U2 - 10.1016/j.mvr.2018.01.005

DO - 10.1016/j.mvr.2018.01.005

M3 - Article

VL - 117

SP - 57

EP - 60

JO - Microvascular Research

JF - Microvascular Research

SN - 0026-2862

ER -