Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity
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Highlights
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The role of the C7-OH group in the activity of cylindrospermopsin 1 is unknown.
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Synthetic analogues (11a–c) of cylindrospermopsin 1 were prepared.
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Toxicity of these analogues was compared with 1 using human neutrophils in vitro.
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The greatest toxicity was found in 11c with a 6-carbon tether and an –OH group.
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An analogue closely resembling 1 but lacking the C7-OH group had low toxicity.
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The role of the C7-OH group in the activity of cylindrospermopsin 1 is unknown.
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Synthetic analogues (11a–c) of cylindrospermopsin 1 were prepared.
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Toxicity of these analogues was compared with 1 using human neutrophils in vitro.
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The greatest toxicity was found in 11c with a 6-carbon tether and an –OH group.
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An analogue closely resembling 1 but lacking the C7-OH group had low toxicity.
Allweddeiriau
| Iaith wreiddiol | Saesneg |
|---|---|
| Tudalennau (o-i) | 172-181 |
| Cyfnodolyn | Toxicology in Vitro |
| Cyfrol | 44 |
| Dyddiad ar-lein cynnar | 10 Gorff 2017 |
| Dynodwyr Gwrthrych Digidol (DOIs) | |
| Statws | Cyhoeddwyd - Hyd 2017 |
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