Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity
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DOI
Highlights
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The role of the C7-OH group in the activity of cylindrospermopsin 1 is unknown.
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Synthetic analogues (11a–c) of cylindrospermopsin 1 were prepared.
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Toxicity of these analogues was compared with 1 using human neutrophils in vitro.
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The greatest toxicity was found in 11c with a 6-carbon tether and an –OH group.
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An analogue closely resembling 1 but lacking the C7-OH group had low toxicity.
•
The role of the C7-OH group in the activity of cylindrospermopsin 1 is unknown.
•
Synthetic analogues (11a–c) of cylindrospermopsin 1 were prepared.
•
Toxicity of these analogues was compared with 1 using human neutrophils in vitro.
•
The greatest toxicity was found in 11c with a 6-carbon tether and an –OH group.
•
An analogue closely resembling 1 but lacking the C7-OH group had low toxicity.
Keywords
- Cylindrospermopsin; , Guanidine synthesis, Neutrophils, Oxidative stress, Reactive oxygen species, Superoxide dismutase, Catalase, Glutathione peroxidase
| Original language | English |
|---|---|
| Pages (from-to) | 172-181 |
| Journal | Toxicology in Vitro |
| Volume | 44 |
| Early online date | 10 Jul 2017 |
| DOIs | |
| Publication status | Published - Oct 2017 |
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