Translin-Trax: Considerations for Oncological Therapeutic Targeting

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Translin-Trax: Considerations for Oncological Therapeutic Targeting. / McFarlane, Ramsay J.; Wakeman, Jane A.
Yn: Trends in Cancer, Cyfrol 6, Rhif 6, 06.2020, t. 450-453.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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McFarlane RJ, Wakeman JA. Translin-Trax: Considerations for Oncological Therapeutic Targeting. Trends in Cancer. 2020 Meh;6(6):450-453. Epub 2020 Maw 16. doi: 10.1016/j.trecan.2020.02.014

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McFarlane, Ramsay J. ; Wakeman, Jane A. / Translin-Trax: Considerations for Oncological Therapeutic Targeting. Yn: Trends in Cancer. 2020 ; Cyfrol 6, Rhif 6. tt. 450-453.

RIS

TY - JOUR

T1 - Translin-Trax: Considerations for Oncological Therapeutic Targeting

AU - McFarlane, Ramsay J.

AU - Wakeman, Jane A.

PY - 2020/6

Y1 - 2020/6

N2 - Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.

AB - Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.

KW - Translin-Trax

KW - Dicer

KW - drug development

KW - miRNA

KW - DNA repair

U2 - 10.1016/j.trecan.2020.02.014

DO - 10.1016/j.trecan.2020.02.014

M3 - Article

VL - 6

SP - 450

EP - 453

JO - Trends in Cancer

JF - Trends in Cancer

SN - 2405-8033

IS - 6

ER -