Research Portal

Dr Andrew Pierce

Lecturer (Teaching & Research)

Affiliations

ORCID: 0000-0001-5995-2469

Contact info

Location: Brambell, Room 412

Email: a.pierce@bangor.ac.uk

Current Position: Lecturer, Medical and Health Sciences

Other external Positions: Honorary Lecturer, Division of Cancer Sciences, The University of Manchester

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  1. Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

    A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

  2. MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

    AD, W., NC, A., S, P., E, J., L, Z., R, B., AC, K., A, N., S, T., AJ, W. & A, P., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

  3. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.

    AD, W., Y, L., A, P., L, C. & E, S., 15 Oct 2003, In: Blood. 102, 8, p. 2798-2802

    Research output: Contribution to journal › Article › peer-review

  4. Published

    A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

    AJ, W., A, P., E, J., C, Z., M, A-OD., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Nov 2013, In: Molecular and Cellular Proteomics. 3319 p.

    Research output: Contribution to journal › Article › peer-review

  5. The effect of Bcr-Abl protein tyrosine kinase on maturation and proliferation of primitive haematopoietic cells

    AM, B., R, M., A, P., GS, L., N, R., JA, M. & AD, W., 1 Oct 2000, In: Molecular Medicine. 6, p. 892-902

    Research output: Contribution to journal › Article › peer-review

  6. Published

    Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

    Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L. & Tonks, A., 2020, In: Leukemia. 34, 2, p. 427-440 14 p.

    Research output: Contribution to journal › Article › peer-review

  7. Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

    C, L., CA, E., E, S., A, P., R, M. & AD, W., 3 Sept 2003, In: British Journal of Haematology. 122, 6, p. 985-995

    Research output: Contribution to journal › Article › peer-review

  8. A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

    C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Dec 2014, In: Bioinformatics. p. 549-558

    Research output: Contribution to journal › Article › peer-review

  9. Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.

    CA, E., S, A., A, P. & AD, W., 1 Nov 2002, In: Blood. 100, 9, p. 3164-3174

    Research output: Contribution to journal › Article › peer-review

  10. Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.

    CA, E., Pierce, A., SA, W., E, S., CM, H. & AD, W., 1 Sept 1999, In: Blood. 94, 5, p. 1504-1514

    Research output: Contribution to journal › Article › peer-review

  11. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

    CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 May 2004, In: Blood. p. 3751-3759

    Research output: Contribution to journal › Article › peer-review

  12. Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

    CF, L., S, G., E, R-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Sept 2010, In: Proteomics. 10, 18, p. 3321-3342

    Research output: Contribution to journal › Article › peer-review

  13. Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

    D, X., Pierce, A., N, U-D., AD, W. & PJ, O-L., Feb 2004, In: Cellular Signalling. 16, 2, p. 145-156

    Research output: Contribution to journal › Article › peer-review

  14. THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).

    DD, T., S, S., AJ, W., Pierce, A., O, D-B., L, W., A, K., AD, W. & T, T., 2014, In: Nucleic Acids Research. 42, 19

    Research output: Contribution to journal › Article › peer-review

  15. Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

    DJ, W., RD, U., E, B., A, P., HY, T., J, M., B, G., TD, S., J, G., S, L., TC, S., R, D., AD, W. & S, M., 12 Jun 2013, In: PLoS ONE.

    Research output: Contribution to journal › Article › peer-review

  16. Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

    DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Nov 2002, In: Molecular and Cellular Proteomics. 1, 11, p. 876-884

    Research output: Contribution to journal › Article › peer-review

  17. Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFR activation of the interferon response pathways.

    E, D., C, G., RW, F., RD, U., JR, G., A, P., AD, W. & H, W., Nov 2010, In: Stem Cell Research. 5, 3, p. 226-243

    Research output: Contribution to journal › Article › peer-review

  18. Cellular and Molecular Aspects of Myeloid Cell Proliferation and Development

    Evans, C. A. & Pierce, A., 1996, Blood Cell Biochemistry: Hematopoietic Cell Growth Factors and Their Receptors. Whetton, A. D. & Gordon, J. (eds.). Boston, MA: Springer US, p. 99-120 22 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  19. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

    F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Oct 2013, In: Leukemia. 27, p. 932-940

    Research output: Contribution to journal › Article › peer-review

  20. BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

    F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Jun 2012, In: Journal of Proteomics. 77, p. 14-26

    Research output: Contribution to journal › Article › peer-review

  21. The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

    F, P., MT, S., GV, H., LE, H., EK, A., M, A-OD., M, C., A, P., BJ, H., AD, W. & TL, H., 18 Aug 2014, In: Stem Cells. 32, 9, p. 2324-2337

    Research output: Contribution to journal › Article › peer-review

  22. [Influence of chemotherapeutants and cytokines on growth and transgene expression of bone marrow cells from MT/p210(bcr-abl) transgenic mice]

    H, C., Pierce, A. & T, W., Dec 1999, In: Chinese Journal of Cancer Research. 11, p. 245-248

    Research output: Contribution to journal › Article › peer-review

  23. Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

    HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Aug 2005, In: Leukemia. p. 1851-1853

    Research output: Contribution to journal › Article › peer-review

  24. Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.

    JM, F., CM, H., E, S., A, P., TM, D. & AD, W., Dec 2000, In: Journal of Biological Chemistry. 275, 50, p. 39137-39145

    Research output: Contribution to journal › Article › peer-review

  25. THOC5 couples M-CSF receptor signaling to transcription factor expression.

    L, C., A, P., M, R., MB, G. S., HG, H., L, Z., T, T. & AD, W., Feb 2009, In: Cellular Signalling. 21, 2, p. 309-316

    Research output: Contribution to journal › Article › peer-review

  26. A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.

    L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, In: Blood. p. 1716-1723

    Research output: Contribution to journal › Article › peer-review

  27. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

    M, A-OD., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, In: Natur Protocols.

    Research output: Contribution to journal › Article › peer-review

  28. Published

    HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

    Maiques-Diaz, A., Nicosia, L., Basma, N. J., Romero-Camarero, I., Camera, F., Spencer, G. J., Amaral, F. M. R., Simeoni, F., Wingelhofer, B., Williamson, A. J. K., Pierce, A., Whetton, A. D. & Somervaille, T. C. P., 28 Oct 2022, In: Oncogene. 41, 44, p. 4841-4854 14 p.

    Research output: Contribution to journal › Article › peer-review

  29. Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

    Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, In: Cell Death and Disease. 8, 6, p. e2875-e2875

    Research output: Contribution to journal › Article › peer-review

  30. Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance.

    N, U-D., Pierce, A., SE, T., D, X., AD, W. & PJ, O-L., 13 Feb 2006, In: British Journal of Haematology. 132, 6, p. 774-783

    Research output: Contribution to journal › Article › peer-review

  31. Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer

    Njoku, K., Campbell, A. E., Geary, B., MacKintosh, M. L., Derbyshire, A. E., Kitson, S. J., Sivalingam, V. N., Pierce, A., Whetton, A. D. & Crosbie, E. J., 10 Feb 2021, In: Cancers. 13, 4, p. 718 1 p.

    Research output: Contribution to journal › Article › peer-review

  32. Comprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid

    Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Jul 2021, In: Cancers.

    Research output: Contribution to journal › Article › peer-review

  33. Published

    Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women

    Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da Sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 18 May 2023, In: British Journal of Cancer. 128, 9, p. 1723-1732 10 p.

    Research output: Contribution to journal › Article › peer-review

  34. Published

    Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: Leveraging proteomics and machine learning for biomarker discover

    Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Apr 2024, In: eBioMedicine. 102, p. 105064

    Research output: Contribution to journal › Article › peer-review

  35. ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

    PA, C., EJ, C., M, A-OD., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, In: BMJ Open Respiratory Research.

    Research output: Contribution to journal › Article › peer-review

  36. EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

    Paredes, R., Schneider, M., Stevens, A., White, D. J., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J. R., Connors, K., Wiseman, D. H., Chadwick, J. A., Löffler, H., Teng, H. Y., Lovell, S., Unwin, R., van de Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T. C. P., Pierce, A., Whetton, A. D. & Meyer, S., 1 Jun 2018, In: Nucleic Acids Research. 46, 15, p. 7662-7674 13 p.

    Research output: Contribution to journal › Article › peer-review

  37. EVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

    Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A. & Meyer, S., 20 Oct 2020, In: Cell Death and Disease. 11

    Research output: Contribution to journal › Article › peer-review

  38. EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

    Paredes, R., Schneider, M., Pearson, S., Teng, H. Y., Kelly, J. R., Pierce, A., Somervaille, T. C. P., Whetton, A. D. & Meyer, S., 2020, In: Molecular Biology Reports. 47, 10, p. 8293-8300 8 p.

    Research output: Contribution to journal › Article › peer-review

  39. Proteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia

    Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, In: Journal of Proteome Research.

    Research output: Contribution to journal › Article › peer-review

  40. AXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells

    Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Apr 2019, In: HemaSphere.

    Research output: Contribution to journal › Article › peer-review

  41. Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients

    Pearson, S., Blance, R., Yan, F., Hsieh, Y-C., Geary, B., Amaral, F. M. R., Somervaille, T. C. P., Kirschner, K., Whetton, A. D. & Pierce, A., 30 May 2023, In: PLoS ONE. 18, 5, 16 p., 0286412.

    Research output: Contribution to journal › Article › peer-review

  42. Published

    Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells

    Pearson, S., D. Whitton, A. & Pierce, A., 31 Mar 2022, In: PLoS ONE. 17, 3, 11 p., e0266298.

    Research output: Contribution to journal › Article › peer-review

  43. Transglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility.

    Pierce, A., AD, W., S, M., F, R-K., G, B., KR, C., N, Z. & S, K., 11 Apr 2013, In: Proteomics. 13, 14, p. 2216-2224

    Research output: Contribution to journal › Article › peer-review

  44. The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells.

    Pierce, A., DL, S., LV, J., AD, W. & E, S., 2001, In: The Hematology Journal. 2, 4, p. 257-264

    Research output: Contribution to journal › Article › peer-review

  45. Published

    Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

    Pierce, A., RD, U., A, P., RB, W., DW, S. & AD, W., 1 Jul 2005, In: Molecular and Cellular Proteomics. 4, 7

    Research output: Contribution to journal › Article › peer-review

  46. Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

    Pierce, A., Y, L., HG, H., S, T., PJ, O-L., AD, W. & E, S., 31 Mar 2006, In: British Journal of Haematology. 133, 3, p. 345-352

    Research output: Contribution to journal › Article › peer-review

  47. Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.

    Pierce, A., AD, W., PJ, O-L., J, T., E, S., TM, D. & CM, H., 15 Mar 1998, In: Journal of Cell Science. p. 815-823

    Research output: Contribution to journal › Article › peer-review

  48. Haemopoietic growth factors and leukaemogenesis.

    Pierce, A. & AD, W., 1 May 1997, In: Biochemical Society Transactions. 25, 2, p. 366-370

    Research output: Contribution to journal › Article › peer-review

  49. An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.

    Pierce, A., CM, H., SE, N., E, S., TM, D., JM, L., PJ, O-L., G, W. & AD, W., 23 Mar 1998, In: Journal of Cell Biology. 140, 6, p. 1511-1518

    Research output: Contribution to journal › Article › peer-review

  50. Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

    Pierce, A., RD, U., CA, E., S, G., L, C., L, Z., E, J., CF, L., D, B., MJ, O., CJ, M., DA, B., E, S. & AD, W., 1 May 2008, In: Molecular and Cellular Proteomics. 7, 5, p. 853-863

    Research output: Contribution to journal › Article › peer-review

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