1. 2024
2. Published

   Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: Leveraging proteomics and machine learning for biomarker discover

   Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Apr 2024, In: eBioMedicine. 102, p. 105064

   Research output: Contribution to journal › Article › peer-review

3. 2023
4. Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients

   Pearson, S., Blance, R., Yan, F., Hsieh, Y-C., Geary, B., Amaral, F. M. R., Somervaille, T. C. P., Kirschner, K., Whetton, A. D. & Pierce, A., 30 May 2023, In: PLoS ONE. 18, 5, 16 p., 0286412.

   Research output: Contribution to journal › Article › peer-review

5. Published

   Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women

   Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da Sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 18 May 2023, In: British Journal of Cancer. 128, 9, p. 1723-1732 10 p.

   Research output: Contribution to journal › Article › peer-review

6. THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

   Polenkowski, M., Allister, A. B., Burbano de Lara, S., Pierce, A., Geary, B., El Bounkari, O., Wiehlmann, L., Hoffmann, A., Whetton, A. D., Tamura, T. & Tran, D. D. H., 20 Jan 2023, In: iScience. 26, 1, 105784.

   Research output: Contribution to journal › Article › peer-review

7. 2022
8. Published

   HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

   Maiques-Diaz, A., Nicosia, L., Basma, N. J., Romero-Camarero, I., Camera, F., Spencer, G. J., Amaral, F. M. R., Simeoni, F., Wingelhofer, B., Williamson, A. J. K., Pierce, A., Whetton, A. D. & Somervaille, T. C. P., 28 Oct 2022, In: Oncogene. 41, 44, p. 4841-4854 14 p.

   Research output: Contribution to journal › Article › peer-review

9. Published

   Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells

   Pearson, S., D. Whitton, A. & Pierce, A., 31 Mar 2022, In: PLoS ONE. 17, 3, 11 p., e0266298.

   Research output: Contribution to journal › Article › peer-review

10. 2021

11. Comprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid

    Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Jul 2021, In: Cancers.

    Research output: Contribution to journal › Article › peer-review

12. Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer

    Njoku, K., Campbell, A. E., Geary, B., MacKintosh, M. L., Derbyshire, A. E., Kitson, S. J., Sivalingam, V. N., Pierce, A., Whetton, A. D. & Crosbie, E. J., 10 Feb 2021, In: Cancers. 13, 4, p. 718 1 p.

    Research output: Contribution to journal › Article › peer-review

13. 2020

14. EVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

    Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A. & Meyer, S., 20 Oct 2020, In: Cell Death and Disease. 11

    Research output: Contribution to journal › Article › peer-review

15. EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

    Paredes, R., Schneider, M., Pearson, S., Teng, H. Y., Kelly, J. R., Pierce, A., Somervaille, T. C. P., Whetton, A. D. & Meyer, S., 2020, In: Molecular Biology Reports. 47, 10, p. 8293-8300 8 p.

    Research output: Contribution to journal › Article › peer-review

16. Published

    Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

    Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L. & Tonks, A., 2020, In: Leukemia. 34, 2, p. 427-440 14 p.

    Research output: Contribution to journal › Article › peer-review

17. 2019

18. Oncogenic MYC amplifies mitotic perturbations

    Taylor, S., Littler, S., Sloss, O., Geary, B., Pierce, A. & Whetton, A., 28 Aug 2019, In: Open Biology.

    Research output: Contribution to journal › Article › peer-review

19. AXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells

    Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Apr 2019, In: HemaSphere.

    Research output: Contribution to journal › Article › peer-review

20. Proteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia

    Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, In: Journal of Proteome Research.

    Research output: Contribution to journal › Article › peer-review

21. 2018

22. EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

    Paredes, R., Schneider, M., Stevens, A., White, D. J., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J. R., Connors, K., Wiseman, D. H., Chadwick, J. A., Löffler, H., Teng, H. Y., Lovell, S., Unwin, R., van de Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T. C. P., Pierce, A., Whetton, A. D. & Meyer, S., 1 Jun 2018, In: Nucleic Acids Research. 46, 15, p. 7662-7674 13 p.

    Research output: Contribution to journal › Article › peer-review

23. 2017

24. Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.

    S, P., AJK, W., R, B., TCP, S., S, T., N, A., AD, W. & A, P., 1 Dec 2017, In: Leukemia. 31

    Research output: Contribution to journal › Article › peer-review

25. Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

    Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, In: Cell Death and Disease. 8, 6, p. e2875-e2875

    Research output: Contribution to journal › Article › peer-review

26. 2016

27. Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

    A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

28. Published

    Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

    SA, A., LE, H., E, C., ME, D., K, D., AJ, W., K, K., P, B., LE, P., MT, S., F, P., Pierce, A., M, C., C, N., SM, G., D, V., AD, W. & TL, H., 2016, In: Nature. 534, p. 341-346

    Research output: Contribution to journal › Article › peer-review

29. ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

    PA, C., EJ, C., M, A-OD., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, In: BMJ Open Respiratory Research.

    Research output: Contribution to journal › Article › peer-review

30. MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

    AD, W., NC, A., S, P., E, J., L, Z., R, B., AC, K., A, N., S, T., AJ, W. & A, P., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

31. 2015

32. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

    M, A-OD., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, In: Natur Protocols.

    Research output: Contribution to journal › Article › peer-review

33. 2014

34. A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

    C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Dec 2014, In: Bioinformatics. p. 549-558

    Research output: Contribution to journal › Article › peer-review

35. The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

    F, P., MT, S., GV, H., LE, H., EK, A., M, A-OD., M, C., A, P., BJ, H., AD, W. & TL, H., 18 Aug 2014, In: Stem Cells. 32, 9, p. 2324-2337

    Research output: Contribution to journal › Article › peer-review

36. THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).

    DD, T., S, S., AJ, W., Pierce, A., O, D-B., L, W., A, K., AD, W. & T, T., 2014, In: Nucleic Acids Research. 42, 19

    Research output: Contribution to journal › Article › peer-review

37. 2013
38. Published

    A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

    AJ, W., A, P., E, J., C, Z., M, A-OD., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Nov 2013, In: Molecular and Cellular Proteomics. 3319 p.

    Research output: Contribution to journal › Article › peer-review

39. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

    F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Oct 2013, In: Leukemia. 27, p. 932-940

    Research output: Contribution to journal › Article › peer-review

40. Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

    DJ, W., RD, U., E, B., A, P., HY, T., J, M., B, G., TD, S., J, G., S, L., TC, S., R, D., AD, W. & S, M., 12 Jun 2013, In: PLoS ONE.

    Research output: Contribution to journal › Article › peer-review

41. Transglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility.

    Pierce, A., AD, W., S, M., F, R-K., G, B., KR, C., N, Z. & S, K., 11 Apr 2013, In: Proteomics. 13, 14, p. 2216-2224

    Research output: Contribution to journal › Article › peer-review

42. 2012

43. BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

    F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Jun 2012, In: Journal of Proteomics. 77, p. 14-26

    Research output: Contribution to journal › Article › peer-review

44. Correction: Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation (PLoS ONE)

    Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 2012, In: PLoS ONE. 8, 6

    Research output: Contribution to journal › Article › peer-review

45. 2010

46. Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFR activation of the interferon response pathways.

    E, D., C, G., RW, F., RD, U., JR, G., A, P., AD, W. & H, W., Nov 2010, In: Stem Cell Research. 5, 3, p. 226-243

    Research output: Contribution to journal › Article › peer-review

47. Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

    CF, L., S, G., E, R-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Sept 2010, In: Proteomics. 10, 18, p. 3321-3342

    Research output: Contribution to journal › Article › peer-review

48. 2009

49. THOC5 couples M-CSF receptor signaling to transcription factor expression.

    L, C., A, P., M, R., MB, G. S., HG, H., L, Z., T, T. & AD, W., Feb 2009, In: Cellular Signalling. 21, 2, p. 309-316

    Research output: Contribution to journal › Article › peer-review

50. 2008

51. Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

    Pierce, A., RD, U., CA, E., S, G., L, C., L, Z., E, J., CF, L., D, B., MJ, O., CJ, M., DA, B., E, S. & AD, W., 1 May 2008, In: Molecular and Cellular Proteomics. 7, 5, p. 853-863

    Research output: Contribution to journal › Article › peer-review

52. THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.

    Pierce, A., L, C., HG, H., JR, G., L, Z., BA, W., MB, G. S., T, T., D, S. & AD, W., 15 Apr 2008, In: British Journal of Haematology. 141, 5, p. 641-650

    Research output: Contribution to journal › Article › peer-review

53. 2006

54. Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

    RD, U., DL, S., D, B., CL, W., CJ, M., CA, E., E, J., SA, B., K, B., A, P., E, S. & AD, W., 15 Jun 2006, In: Blood. 107, 12, p. 4687-4694

    Research output: Contribution to journal › Article › peer-review

55. Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

    Pierce, A., Y, L., HG, H., S, T., PJ, O-L., AD, W. & E, S., 31 Mar 2006, In: British Journal of Haematology. 133, 3, p. 345-352

    Research output: Contribution to journal › Article › peer-review

56. Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance.

    N, U-D., Pierce, A., SE, T., D, X., AD, W. & PJ, O-L., 13 Feb 2006, In: British Journal of Haematology. 132, 6, p. 774-783

    Research output: Contribution to journal › Article › peer-review

57. A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.

    L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, In: Blood. p. 1716-1723

    Research output: Contribution to journal › Article › peer-review

58. 2005

59. Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

    HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Aug 2005, In: Leukemia. p. 1851-1853

    Research output: Contribution to journal › Article › peer-review

60. Published

    Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

    Pierce, A., RD, U., A, P., RB, W., DW, S. & AD, W., 1 Jul 2005, In: Molecular and Cellular Proteomics. 4, 7

    Research output: Contribution to journal › Article › peer-review

61. Published

    Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

    RD, U., DW, S., Y, L., A, P., DG, G. & AD, W., Feb 2005, In: Journal of Biological Chemistry. 280, 8, p. 6316-6326

    Research output: Contribution to journal › Article › peer-review

62. 2004

63. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

    CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 May 2004, In: Blood. p. 3751-3759

    Research output: Contribution to journal › Article › peer-review

64. Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

    D, X., Pierce, A., N, U-D., AD, W. & PJ, O-L., Feb 2004, In: Cellular Signalling. 16, 2, p. 145-156

    Research output: Contribution to journal › Article › peer-review

65. 2003

66. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.

    AD, W., Y, L., A, P., L, C. & E, S., 15 Oct 2003, In: Blood. 102, 8, p. 2798-2802

    Research output: Contribution to journal › Article › peer-review

67. Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

    C, L., CA, E., E, S., A, P., R, M. & AD, W., 3 Sept 2003, In: British Journal of Haematology. 122, 6, p. 985-995

    Research output: Contribution to journal › Article › peer-review

68. 2002

69. Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

    DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Nov 2002, In: Molecular and Cellular Proteomics. 1, 11, p. 876-884

    Research output: Contribution to journal › Article › peer-review

70. Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.

    CA, E., S, A., A, P. & AD, W., 1 Nov 2002, In: Blood. 100, 9, p. 3164-3174

    Research output: Contribution to journal › Article › peer-review

71. BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.

    Pierce, A., E, S., S, A. & AD, W., 2002, In: Oncogene. 21, p. 3068-3075

    Research output: Contribution to journal › Article › peer-review