1. Published

   Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England

   Harron, K., Mok, Q., Hughes, D., Muller-Pebody, B., Parslow, R., Ramnarayan, P. & Gilbert, R., 21 Mar 2016, In: PLoS ONE. 11, 3, p. e0151348

   Research output: Contribution to journal › Article › peer-review

2. Published

   Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series

   Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., Livingston, M., Javed, A., Moreno, G. Y. C., Watt, T., Stedman, M. & Hughes, D., 28 Dec 2021, In: International Journal of Clinical Practice. 75, 12, e14967.

   Research output: Contribution to journal › Article › peer-review

3. Published

   Impact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout

   Hill McManus, D., Soto, E., Marshall, S., Lane, S. & Hughes, D., Jan 2018, In: British Journal of Clinical Pharmacology. 84, 1, p. 142-152

   Research output: Contribution to journal › Article › peer-review

4. Published

   Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout

   Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sept 2019, In: Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660

   Research output: Contribution to journal › Article › peer-review

5. Published

   Combining model-based clinical trial simulation, pharmacoeconomics and value of information to optimize trial design

   Hill-McManus, D. & Hughes, D., Jan 2021, In: CPT: Pharmacometrics & Systems Pharmacology . 10, 1, p. 75-83 9 p.

   Research output: Contribution to journal › Article › peer-review

6. Published

   Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data

   Hill-McManus, D. & Hughes, D., Jun 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2782-2792 11 p.

   Research output: Contribution to journal › Article › peer-review

7. Published

   Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development

   Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 49-63

   Research output: Contribution to journal › Article › peer-review

8. Published

   Impact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model

   Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Dec 2018, In: Value in Health. 21, 12, p. 1373-1381

   Research output: Contribution to journal › Article › peer-review

9. Published

   What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients

   Holmes, E. A., Morrison, V. L. & Hughes, D., Aug 2016, In: British Journal of Clinical Pharmacology. 82, 2, p. 522-531

   Research output: Contribution to journal › Article › peer-review

10. Published

    A new taxonomy for describing and defining adherence to medications

    Holmes, E. A., Hughes, D., Morrison, V. L., Vrijens, B., De Geest, S., Hughes, D. A., Prezemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., Matyjaszczyk, M., Mshelia, C., Clyne, W., Aronson, J. K. & Urquhart, J., 1 May 2012, In: British Journal of Clinical Pharmacology. 73, 5, p. 691-705

    Research output: Contribution to journal › Article › peer-review

11. Published

    New advice on switching antiepileptic drugs might be a false economy

    Holmes, E. A., Plumpton, C. O., Hughes, D., Holmes, E., Plumpton, C., Duerden, M., Marson, T. & Hughes, D. A., 16 Dec 2013, In: British Medical Journal. 347

    Research output: Contribution to journal › Article › peer-review

12. Published

    Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research

    Holmes, E. A., Morrison, V. L. & Hughes, D., 8 Dec 2014, In: Value in Health. 17, 8, p. 863-876

    Research output: Contribution to journal › Article › peer-review

13. Published

    Developing an alternative care pathway for emergency ambulance responses for adults with epilepsy: A Discrete Choice Experiment to understand which configuration service users prefer. Part of the COLLABORATE project

    Holmes, E., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., McKinlay, A., Dickson, J., Goodacre, S., Jackson, M., Foster, D., Hardman, K., Bell, S., Marson, A., Hughes, D. & Noble, A. J., Apr 2024, In: Seizure: European Journal of Epilepsy. 118, p. 28-37 10 p.

    Research output: Contribution to journal › Article › peer-review

14. Published

    Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care

    Holmes, E., Harris, S. D., Hughes, A., Craine, N. & Hughes, D., 7 Dec 2018, In: Antibiotics. 7, 4, 19 p., 106.

    Research output: Contribution to journal › Article › peer-review

15. Published

    Balancing Patient Preferences With Feasible Healthcare Delivery: Using Discrete Choice Experiments Alongside Knowledge Exchange To Inform Care Pathways. International Journal of Technology Assessment in Health Care.

    Holmes, E., Morris, B., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., Goodacre, S., Jackson, M. & Hughes, D., 7 Jan 2025, In: International Journal of Technology Assessment in Health Care. 40, S1, p. 178

    Research output: Contribution to journal › Meeting Abstract › peer-review

16. Published

    Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT

    Holmes, E., Noble, A. J., Nevitt, S., Holmes, E., Ridsdale, L., Morgan, M., Smith, C. T., Hughes, D., Goodacre, S., Marson, T. & Snape, D. A., 1 Oct 2020, In: Health and Social Care Delivery Research. 8, 39

    Research output: Contribution to journal › Article › peer-review

17. Published

    A model-based cost-utility analysis of an automated notification system for deteriorating patients on general wards

    Holmes, E., Hughes, D. & Subbe, C., 2 May 2024, In: PLoS ONE. 19, 5, p. e0301643 e0301643.

    Research output: Contribution to journal › Article › peer-review

18. Published

    Patient preferences for outcomes in clinical trials: implications for medicines optimization

    Holmes, E., Marson, A. G. & Hughes, D., 8 May 2017, In: Trials. 18 (Suppl 1), O18, p. 192 1 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

19. Published

    Challenges for economic evaluation of strategies to contain antimicrobial resistance

    Holmes, E. & Hughes, D., 27 Sept 2019, In: Antibiotics. 8, 4, 8 p., 166.

    Research output: Contribution to journal › Comment/debate › peer-review

20. Published

    Automated Systems For Hospital Inpatient Safety: A Cost-Utility Analysis.

    Holmes, E., Lloyd-Williams, H., Hughes, D. & Subbe, C., 7 Jan 2025, In: International Journal of Technology Assessment in Health Care. 40, S1, p. S100

    Research output: Contribution to journal › Meeting Abstract › peer-review

21. Published

    Influence Of Disease Familiarity On Implied Time Preferences For Seizure Frequency Reduction.

    Holmes, E., Morrison, V. & Hughes, D., 1 Oct 2017, In: Value in Health. 20, 9, PA689.

    Research output: Contribution to journal › Meeting Abstract › peer-review

22. Published

    1151 Patients’ preferences for anti-epileptic drugs (aeds)

    Holmes, E., Baker, G. A., Jacoby, A., Ring, A., Marson, A. & Hughes, D., 2017, In: Journal of Neurology, Neurosurgery and Psychiatry. 88, S1, 3 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

23. Published

    Patient-focused drug development methods for benefit-risk assessments: A case study using discrete choice experiment for antiepileptic drugs

    Holmes, E. A. F., Plumpton, C., Baker, G. A., Jacoby, A., Ring, A., Williamson, P., Marson, A. & Hughes, D. A., Mar 2019, In: Clinical Pharmacology and Therapeutics. 105, 3, p. 672-683 12 p.

    Research output: Contribution to journal › Article › peer-review

24. Published

    Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.

    Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.

    Research output: Contribution to journal › Article › peer-review

25. Published

    The economics of evergreening.

    Hughes, D. & Hughes, D. A., 1 Jan 2009.

    Research output: Contribution to conference › Paper

26. Published

    Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity

    Hughes, D., Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K. & Pirmohamed, M., 1 Jun 2004, In: Pharmacogenetics. 14, 6, p. 335-342

    Research output: Contribution to journal › Article › peer-review

27. Published

    Drugs for exceptionally rare diseases: do they deserve special status for funding?

    Hughes, D., Tunnage, B. & Yeo, S. T., 1 Nov 2005, In: QJM - An International Journal of Medicine. 98, 11, p. 829-836

    Research output: Contribution to journal › Article › peer-review

28. Published

    Is exercise effective in promoting mental well-being in older age? A systematic review.

    Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T. & Woods, R. T., 1 Aug 2010, In: Aging and Mental Health. 14, 6, p. 652-669

    Research output: Contribution to journal › Article › peer-review

29. Published

    Cost–effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs

    Hughes, D., Verhof, T. I., Redekop, W. K., van Schie, R. M., Bayat, S., Daly, A. K., Geitona, M., Haschke-Becher, E., Hughes, D. A., Kamali, F., Levin, L. A., Manolopoulos, V. G., Pirmohamed, M., Siebert, U., Stingl, J. C., Wadelius, M., de Boer, A. & Maitland-van der Zee, A. H., 1 Sept 2012, In: Pharmacogenomics. 13, 12, p. 1405-1417

    Research output: Contribution to journal › Article › peer-review

30. Published

    A parenting programme for children at risk of developing conduct disorder: A cost-effectiveness analysis

    Hughes, D., Edwards, R. T., Ceilleachair, A., Bywater, T., Hughes, D. A. & Hutchings, J., 1 May 2007.

    Research output: Contribution to conference › Paper

31. Published

    Economic evaluations during early (Phase II) drug development: A role for clinical trial simulations.

    Hughes, D., Hughes, D. A. & Walley, T., 1 Jan 2001, In: Pharmacoeconomics. 19, 11, p. 1069-1077

    Research output: Contribution to journal › Article › peer-review

32. Published

    Investigating factors influencing user choices to visit either general practitioners or community pharmacists in the management of minor ailments – piloting a discrete choice experiment

    Hughes, D., Hughes, D. A., Myles, S., Longo, M. & Lisles, C., 1 Mar 2008

    Research output: Non-textual form › Web publication/site

33. Published

    Drug compliance and pharmaceconomics

    Hughes, D. & Hughes, D. A., 1 Dec 2003.

    Research output: Contribution to conference › Paper

34. Published

    All Wales Medicines Strategy Group Final Appraisal Report – Parathyroid hormone (Preotact)

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.

    Research output: Book/Report › Commissioned report

35. Published

    Methodological issues in the literature on costs of non-compliance in chronic diseases

    Hughes, D., Salas, M., Zuluaga, A., Hughes, D. A., Cowell, W., Lebmeie, M., Vardeva, K., Pisu, M. & Shinogle, J., 1 Nov 2008.

    Research output: Contribution to conference › Paper

36. Published

    Economic evaluation during early (phase II) trials

    Hughes, D. & Hughes, D. A., 1 Nov 2002.

    Research output: Contribution to conference › Paper

37. Published

    Impact of the abolition of the prescription charge in Wales

    Hughes, D. & Hughes, D. A., 1 Nov 2008.

    Research output: Contribution to conference › Paper

38. Published

    A prototype agent-based model of antimalarial drug compliance

    Hughes, D., McKean, J., Rahlf, S., Shorter, H., Barnish, G., Paton, R., McBurney, P., Hughes, D. A. & Hastings, I., 1 Aug 2007.

    Research output: Contribution to conference › Paper

39. Published

    Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?

    Hughes, D., Hughes, D. A. & Pirmohamed, M., 1 Nov 2003, In: Value in Health. 6, 6, p. 749

    Research output: Contribution to journal › Article › peer-review

40. Published

    Biosimilars: Evidential standards for health technology assessment.

    Hughes, D. & Hughes, D. A., 1 Jan 2009.

    Research output: Contribution to conference › Paper

41. Published

    Abolition of prescription copayments in Wales: an observational study on dispensing rates.

    Hughes, D., Cohen, D., Alam, M. F., Dunstan, F. D., Myles, S., Hughes, D. A. & Routledge, P. A., 1 Aug 2010, In: Value in Health. 13, 5, p. 675-680

    Research output: Contribution to journal › Article › peer-review

42. Published

    Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations.

    Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Nov 2007, In: Value in Health. 10, 6, p. 498-509

    Research output: Contribution to journal › Article › peer-review

43. Published

    Effects of the abolition of prescription charges in Wales: A preliminary analysis

    Hughes, D., Hughes, D. A., Alam, F., Cohen, D., Dunstan, F. & Routledge, P., 1 Apr 2008.

    Research output: Contribution to conference › Paper

44. Published

    Pharmacogenetic tests: the need for a level playing field

    Hughes, D., Pirmohamed, M. & Hughes, D. A., 1 Jan 2013, In: Nature Reviews Drug Discovery. 12, 3-4

    Research output: Contribution to journal › Article › peer-review

45. Published

    What determines which interventions improve compliance, and do they improve health outcomes in a cost-effective manner?

    Hughes, D., Hughes, D. A., LaFleur.*, [. V., Salas, M. & Shinogle, J., 1 May 2007.

    Research output: Contribution to conference › Paper

46. Published

    All Wales Medicines Strategy Group Final Appraisal Report - Atazanavir (Reyataz) in treatment-experienced patients.

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.

    Research output: Book/Report › Commissioned report

47. Published

    Adverse drug reactions in economic evaluations

    Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Value in Health. 10, 3, p. A109

    Research output: Contribution to journal › Article › peer-review

48. Published

    All Wales Medicines Strategy Group Final Appraisal Report - Tenofovir disoproxil fumarate (Viread) for the treatment of hepatitis B.

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.

    Research output: Book/Report › Commissioned report

49. Published

    The influence of non-compliance on the effectiveness and cost-effectiveness of drug therapies.

    Hughes, D. & Hughes, D. A., 1 Jan 2001, 2001 ed. Unknown.

    Research output: Book/Report › Commissioned report

50. Published

    All Wales Medicines Strategy Group Final Appraisal Report – Clofarabine (Evoltra)

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.

    Research output: Book/Report › Commissioned report