Professor Dyfrig Hughes

Athro mewn Ffarmacoeconomeg / Cyfarwyddwr Ymchwil

Affiliations

North Wales Medical School

Links

http://cheme.bangor.ac.uk

ORCID: 0000-0001-8247-7459

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Article › Research › Peer-reviewed
Published

Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis
Hughes, D., Holmes, E. A., Demonceau, J., Ruppar, T., Kristano, P., Hughes, A. D., Fargher, E., Przemyslaw, K., De Geest, S., Dobbels, F., Lewek, P., Urquhart, J. & Vrijens, B., 1 May 2013, In: Drugs. 73, 6, p. 545-562
Research output: Contribution to journal › Article › peer-review
Published

Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group
Hughes, D., Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A. & Grubisic, M., 1 Jul 2013, In: Value in Health. 16, 5, p. 863-871
Research output: Contribution to journal › Article › peer-review
Published

Impact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model
Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Dec 2018, In: Value in Health. 21, 12, p. 1373-1381
Research output: Contribution to journal › Article › peer-review
Published

Impact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout
Hill McManus, D., Soto, E., Marshall, S., Lane, S. & Hughes, D., Jan 2018, In: British Journal of Clinical Pharmacology. 84, 1, p. 142-152
Research output: Contribution to journal › Article › peer-review
Published

Impact of non-compliance on the cost-effectiveness of statin therapy
Hughes, D., Hughes, D. A. & Bagust, A., 1 Sept 2001, In: Value in Health. 4, 6, p. 489
Research output: Contribution to journal › Article › peer-review
Published

Impact of relaxing Covid-19 social distancing measures on rural North Wales: a simulation analysis
Hughes, R. P. & Hughes, D., 14 Dec 2020, In: Frontiers in Public Health. 8, 562473.
Research output: Contribution to journal › Article › peer-review
Published

Impact on the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales
Alam, M. F., Cohen, D., Dunstan, F., Hughes, D. & Routledge, P. A., Jan 2018, In: Health Economics. 27, 1, p. 236-243
Research output: Contribution to journal › Article › peer-review
Published

Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial
Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., Ramnarayan, P., Tibby, S. M., Hughes, D. & Gamble, C. F., 23 Apr 2016, In: The Lancet. 387, 10029, p. 1732-1742
Research output: Contribution to journal › Article › peer-review
Published

Improving medication adherence in the community: a purposive umbrella review of effective patient-directed interventions that are readily implementable in the United Kingdom National Health Service
Mackridge, A., Wood, E. & Hughes, D., 14 Mar 2025, In: International Journal of Clinical Pharmacy.
Research output: Contribution to journal › Article › peer-review
Published

Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care
Swift, B., Jain, L., White, C., Chandrasekaran, V., Bhandari, A., Hughes, D. & Jadhav, P., Sept 2018, In: Clinical and Translational Science. 11, 5, p. 450-460 11 p.
Research output: Contribution to journal › Article › peer-review
Published

Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout
Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sept 2019, In: Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660
Research output: Contribution to journal › Article › peer-review
Published

Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group
Hughes, D., Linck, P. G., Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F. H., Linck, P. & Cowell, W., 1 Dec 2013, In: Osteoporosis International. 24, 12, p. 2907-2918
Research output: Contribution to journal › Article › peer-review
Published

Is exercise effective in promoting mental well-being in older age? A systematic review.
Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T. & Woods, R. T., 1 Aug 2010, In: Aging and Mental Health. 14, 6, p. 652-669
Research output: Contribution to journal › Article › peer-review
Published

Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series
Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., Livingston, M., Javed, A., Moreno, G. Y. C., Watt, T., Stedman, M. & Hughes, D., 28 Dec 2021, In: International Journal of Clinical Practice. 75, 12, e14967.
Research output: Contribution to journal › Article › peer-review
Published

Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs
Marson, A. G., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P. R., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., Dec 2021, In: Health Technology Assessment. 25, 75, 162 p.
Research output: Contribution to journal › Article › peer-review
Published

Less is more: Medicines that require less frequent administration improve adherence, but are they better?
Hughes, D. & Hughes, D. A., 1 Jan 2006, In: Pharmacoeconomics. 24, 3, p. 211-213
Research output: Contribution to journal › Article › peer-review
Published

Lessons learnt from a discontinued randomised controlled trial: Adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)
Williams, N., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D., Wood, E., Foster, N. E., Walsh, D. A., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S. & Wilkinson, C., 31 Jul 2018, In: Trials. 19, 408.
Research output: Contribution to journal › Article › peer-review
Published

Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development
Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 49-63
Research output: Contribution to journal › Article › peer-review
Published

Liothyronine for hypothyroidism: A candidate for disinvestment or in need of further research? A value of information analysis
Hughes, D., Skiadas, K., Fitzsimmons, D., Anderson, P. & Heald, A., 3 Dec 2021, In: BMJ Open. 11, 12, e051702.
Research output: Contribution to journal › Article › peer-review
Published

Managing Access to Advanced Therapy Medicinal Products: Challenges for NHS Wales
Champion, A. R., Lewis, S., Davies, S. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2444-2449
Research output: Contribution to journal › Article › peer-review
Published

Mapping ALSFRS-R and ALSUI to EQ-5D in patients with motor neurone disease
Moore, A., Young, C. A. & Hughes, D., Nov 2018, In: Value in Health. 21, 11, p. 1322-1329
Research output: Contribution to journal › Article › peer-review
Published

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
Hughes, D., Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., Hughes, D. A., Molyneux, M. E., Ward, S. A., Winstanley, P. A. & Lalloo, D. G., 26 Aug 2009, In: Malaria Journal. 8, p. 204
Research output: Contribution to journal › Article › peer-review
Published

Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.
Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.
Research output: Contribution to journal › Article › peer-review
Published

Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial
Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., Sharma, M., Frank, B., Bassett, P., Marshall, A. & Goebel, A., 6 Nov 2021, In: Journal of Translational Medicine. 19, 1, 458.
Research output: Contribution to journal › Article › peer-review
Published

Medicines concordance and game theory.
Hughes, D. & Hughes, D. A., 1 Oct 2008, In: British Journal of Clinical Pharmacology. 66, 4, p. 577
Research output: Contribution to journal › Article › peer-review

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