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  • Barbara Costa Beber
    Federal University of Health Sciences of Porto Alegre
  • Maria Luisa Mandelli
    University of California, San Francisco
  • Miguel A Santos-Santos
  • Richard J Binney
    University of California, San Francisco
  • Bruce L Miller
    University of California, San Francisco
  • Marcia Chaves
    Federal University of Rio Grande
  • Maria Luisa Gorno-Tempini
    University of California, San Francisco
  • Kevin Shapiro
    University of California, San Francisco
Background: Patients with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) have more difficulty producing verbs than nouns, but the reason for this discrepancy remains unclear. One possibility is that it results from impaired access to motor programs integral to semantic representations of actions. Another is that the disruption affects specific lexical or grammatical features of verbs. Aims: To use an oral picture naming task to examine the effects of motor associations on verb production in patients with nfvPPA. Methods & Procedures: We administered noun and verb naming tasks to 12 nfvPPA patients and 9 controls. We varied the manipulability of target items across categories as a proxy for the degree to which lexical access depends on motor knowledge. Outcomes & Results: Nonfluent PPA patients were significantly more impaired in both noun and verb naming compared to control participants. However, the nfvPPA patients were significantly more impaired in naming verbs than nouns, but there was no effect of manipulability. Conclusion: The results suggest that the verb naming deficit in nfvPPA is not directly related to impaired motor knowledge, and is more likely to be related to other properties that distinguish verbs from nouns.

Keywords

  • Primary progressive aphasia, Grammatical dissociation, Verb, Nouns, Semantics, Naming
Original languageEnglish
Pages (from-to)200-215
JournalAphasiology
Volume33
Issue number2
Early online date29 Apr 2018
DOIs
Publication statusPublished - Feb 2019
Externally publishedYes
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