Electronic versions


  • 2019-Black phosphorus based fiber optic

    Accepted author manuscript, 1 MB, PDF document

    Embargo ends: 25/04/21


We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating
ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.
Original languageEnglish
Pages (from-to)140-147
Number of pages8
JournalBiosensors and Bioelectronics
Early online date25 Apr 2019
Publication statusPublished - 15 Jul 2019
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