Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

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Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis. / Zhou, Lin; Liu, Chen; Sun, Zhengbo et al.
In: Biosensors and Bioelectronics, Vol. 137, 15.07.2019, p. 140-147.

Research output: Contribution to journalArticlepeer-review

HarvardHarvard

Zhou, L, Liu, C, Sun, Z, Mao, H, Zhang, L, Yu, X, Zhao, J & Chen, X 2019, 'Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis', Biosensors and Bioelectronics, vol. 137, pp. 140-147. https://doi.org/10.1016/j.bios.2019.04.044

APA

Zhou, L., Liu, C., Sun, Z., Mao, H., Zhang, L., Yu, X., Zhao, J., & Chen, X. (2019). Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis. Biosensors and Bioelectronics, 137, 140-147. https://doi.org/10.1016/j.bios.2019.04.044

CBE

Zhou L, Liu C, Sun Z, Mao H, Zhang L, Yu X, Zhao J, Chen X. 2019. Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis. Biosensors and Bioelectronics. 137:140-147. https://doi.org/10.1016/j.bios.2019.04.044

MLA

VancouverVancouver

Zhou L, Liu C, Sun Z, Mao H, Zhang L, Yu X et al. Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis. Biosensors and Bioelectronics. 2019 Jul 15;137:140-147. Epub 2019 Apr 25. doi: 10.1016/j.bios.2019.04.044

Author

Zhou, Lin ; Liu, Chen ; Sun, Zhengbo et al. / Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis. In: Biosensors and Bioelectronics. 2019 ; Vol. 137. pp. 140-147.

RIS

TY - JOUR

T1 - Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

AU - Zhou, Lin

AU - Liu, Chen

AU - Sun, Zhengbo

AU - Mao, Hongju

AU - Zhang, Lin

AU - Yu, Xuefeng

AU - Zhao, Jianlong

AU - Chen, Xianfeng

N1 - Supplementary data related to this article can be found at https://doi.org/10.1016/j.bios.2019.04.044. The authors acknowledge support from the projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto Bio, European Commission); the Sêr Cymru NRN Fund (NRN097, United Kingdom); the National Natural Science Foundation of China (No. 61571429 and 61801464, China).

PY - 2019/7/15

Y1 - 2019/7/15

N2 - We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstratingultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

AB - We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstratingultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

U2 - 10.1016/j.bios.2019.04.044

DO - 10.1016/j.bios.2019.04.044

M3 - Article

VL - 137

SP - 140

EP - 147

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

SN - 0956-5663

ER -