C2-Symmetric Amino Acid Amide-Derived Organocatalysts
Research output: Contribution to journal › Article › peer-review
Electronic versions
Links
- https://doi.org/10.3390/reactions5030027
Final published version
Licence: CC BY Show licence
N-alkylated C2-symmetric amino acid amide derivatives were shown to catalyse the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 44%. The corresponding trifluoroacetic acid salts also catalysed the aldol reaction between 4-nitrobenzaldehyde and hydroxyacetone, leading to the formation of predominantly syn-aldol products in up to 55% ee. Aspects of the solvent dependence of the aldol reaction and the H-bonding of the catalyst were investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 567-586 |
| Journal | Reactions |
| Volume | 5 |
| Issue number | 3 |
| Publication status | Published - 24 Aug 2024 |