TY - JOUR

T1 - Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2 max

AU - Bishop, Nicolette C.

AU - Blannin, Andrew K.

AU - Walsh, Neil

AU - Gleeson, Michael

PY - 2001/4

Y1 - 2001/4

N2 - Carbohydrate (CHO) beverage ingestion appears to influence neutrophil functional responses to prolonged exercise of a fixed duration. The aim of this randomised study was to examine the effect of CHO (5% w/v) beverage ingestion on lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses in nine recreationally active males who cycled at 75% VO2 max until fatigue. On two separate occasions, subjects ingested either placebo (PLA) or CHO beverages before and at 15 min intervals during the exercise. Subjects exercised for 31% longer on the CHO trial compared with the PLA trial (P < 0.05). At fatigue plasma glucose concentration was significantly lower on the PLA trial compared with the CHO trial (P < 0.05). Plasma cortisol concentrations had increased similarly on both trials at this time. A marked neutrophilia was evident at fatigue and throughout the 4 h recovery period, the magnitude of which was similar on both trials. At fatigue LPS-stimulated elastase release per neutrophil had fallen similarly on both trials compared with pre-exercise values (47% and 50% on the PLA and CHO trials, respectively). In conclusion, our results suggest that CHO beverage ingestion has negligible influence on the hormonal, circulating neutrophil and LPS-stimulated neutrophil degranulation responses when exercise is performed to fatigue.

AB - Carbohydrate (CHO) beverage ingestion appears to influence neutrophil functional responses to prolonged exercise of a fixed duration. The aim of this randomised study was to examine the effect of CHO (5% w/v) beverage ingestion on lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses in nine recreationally active males who cycled at 75% VO2 max until fatigue. On two separate occasions, subjects ingested either placebo (PLA) or CHO beverages before and at 15 min intervals during the exercise. Subjects exercised for 31% longer on the CHO trial compared with the PLA trial (P < 0.05). At fatigue plasma glucose concentration was significantly lower on the PLA trial compared with the CHO trial (P < 0.05). Plasma cortisol concentrations had increased similarly on both trials at this time. A marked neutrophilia was evident at fatigue and throughout the 4 h recovery period, the magnitude of which was similar on both trials. At fatigue LPS-stimulated elastase release per neutrophil had fallen similarly on both trials compared with pre-exercise values (47% and 50% on the PLA and CHO trials, respectively). In conclusion, our results suggest that CHO beverage ingestion has negligible influence on the hormonal, circulating neutrophil and LPS-stimulated neutrophil degranulation responses when exercise is performed to fatigue.

KW - Adult

KW - Beverages

KW - Bicycling

KW - Blood Glucose

KW - Body Mass Index

KW - Cell Degranulation

KW - Dietary Carbohydrates

KW - Exercise

KW - Fatigue

KW - Heart Rate

KW - Humans

KW - Hydrocortisone

KW - Insulin

KW - Lactic Acid

KW - Leukocyte Count

KW - Male

KW - Neutrophils

KW - Pancreatic Elastase

KW - Physical Exertion

KW - Plasma Volume

KW - Clinical Trial

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1055/s-2001-16386

DO - 10.1055/s-2001-16386

M3 - Article

C2 - 11354527

VL - 22

SP - 226

EP - 231

JO - International Journal of Sports Medicine

JF - International Journal of Sports Medicine

SN - 0172-4622

IS - 3

ER -