Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2 max
Research output: Contribution to journal › Article › peer-review
Electronic versions
DOI
Carbohydrate (CHO) beverage ingestion appears to influence neutrophil functional responses to prolonged exercise of a fixed duration. The aim of this randomised study was to examine the effect of CHO (5% w/v) beverage ingestion on lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses in nine recreationally active males who cycled at 75% VO2 max until fatigue. On two separate occasions, subjects ingested either placebo (PLA) or CHO beverages before and at 15 min intervals during the exercise. Subjects exercised for 31% longer on the CHO trial compared with the PLA trial (P < 0.05). At fatigue plasma glucose concentration was significantly lower on the PLA trial compared with the CHO trial (P < 0.05). Plasma cortisol concentrations had increased similarly on both trials at this time. A marked neutrophilia was evident at fatigue and throughout the 4 h recovery period, the magnitude of which was similar on both trials. At fatigue LPS-stimulated elastase release per neutrophil had fallen similarly on both trials compared with pre-exercise values (47% and 50% on the PLA and CHO trials, respectively). In conclusion, our results suggest that CHO beverage ingestion has negligible influence on the hormonal, circulating neutrophil and LPS-stimulated neutrophil degranulation responses when exercise is performed to fatigue.
Keywords
- Adult, Beverages, Bicycling, Blood Glucose, Body Mass Index, Cell Degranulation, Dietary Carbohydrates, Exercise, Fatigue, Heart Rate, Humans, Hydrocortisone, Insulin, Lactic Acid, Leukocyte Count, Male, Neutrophils, Pancreatic Elastase, Physical Exertion, Plasma Volume, Clinical Trial, Journal Article, Randomized Controlled Trial
Original language | English |
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Pages (from-to) | 226-31 |
Number of pages | 6 |
Journal | International Journal of Sports Medicine |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr 2001 |
Externally published | Yes |