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COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures

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COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. / Saville, C.W.; Lancaster, T.M.; Stefanou, M.E. et al.
In: Neuroimage, Vol. 100, 14.06.2014, p. 489-497.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Saville, CW, Lancaster, TM, Stefanou, ME, Salunkhe, G, Lourmpa, I, Nadkarni, A, Boehm, SG, Bender, S, Smyrnis, N, Ettinger, U, Feige, B, Biscaldi, M, Mantripragadah, KK, Linden, DE & Klein, C 2014, 'COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures', Neuroimage, vol. 100, pp. 489-497. https://doi.org/10.1016/j.neuroimage.2014.06.006

APA

Saville, C. W., Lancaster, T. M., Stefanou, M. E., Salunkhe, G., Lourmpa, I., Nadkarni, A., Boehm, S. G., Bender, S., Smyrnis, N., Ettinger, U., Feige, B., Biscaldi, M., Mantripragadah, K. K., Linden, D. E., & Klein, C. (2014). COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. Neuroimage, 100, 489-497. https://doi.org/10.1016/j.neuroimage.2014.06.006

CBE

Saville CW, Lancaster TM, Stefanou ME, Salunkhe G, Lourmpa I, Nadkarni A, Boehm SG, Bender S, Smyrnis N, Ettinger U, et al. 2014. COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. Neuroimage. 100:489-497. https://doi.org/10.1016/j.neuroimage.2014.06.006

MLA

Saville, C.W. et al. "COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures". Neuroimage. 2014, 100. 489-497. https://doi.org/10.1016/j.neuroimage.2014.06.006

VancouverVancouver

Saville CW, Lancaster TM, Stefanou ME, Salunkhe G, Lourmpa I, Nadkarni A et al. COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. Neuroimage. 2014 Jun 14;100:489-497. doi: 10.1016/j.neuroimage.2014.06.006

Author

Saville, C.W. ; Lancaster, T.M. ; Stefanou, M.E. et al. / COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. In: Neuroimage. 2014 ; Vol. 100. pp. 489-497.

RIS

TY - JOUR

T1 - COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures

AU - Saville, C.W.

AU - Lancaster, T.M.

AU - Stefanou, M.E.

AU - Salunkhe, G.

AU - Lourmpa, I.

AU - Nadkarni, A.

AU - Boehm, S.G.

AU - Bender, S.

AU - Smyrnis, N.

AU - Ettinger, U.

AU - Feige, B.

AU - Biscaldi, M.

AU - Mantripragadah, K.K.

AU - Linden, D.E.

AU - Klein, C.

PY - 2014/6/14

Y1 - 2014/6/14

N2 - Intra-subject variability in reaction times (ISV) is a promising endophenotype for several psychiatric conditions, but its neural underpinnings are not yet established. Converging evidence from neuroimaging, molecular genetics, and psychopharmacology suggests that ISV could index catecholaminergically-mediated neural noise. The fine-grained temporal resolution of electroencephalography is ideal for investigating ISV, but only if potential neural correlates of ISV can be assessed in single trials. Based on evidence that ISV is associated with dopaminergic functioning, we apply a recently developed method of single-trial P3b analysis to investigate the association of COMT Val158Met genotype with measures of ISV on the behavioural and neural levels at different working memory loads. Greater number of Met alleles was associated with poorer and more intra-individually variable performance on the tasks, and greater latency jitter in single-trial P3bs. These converging results at the behavioural and neurophysiological levels confirm previous observations that prefrontal dopamine availability is associated with stability and accuracy of cognitive performance. Together with previous studies, these data imply pleiotropic cognitive effects of COMT genotype.

AB - Intra-subject variability in reaction times (ISV) is a promising endophenotype for several psychiatric conditions, but its neural underpinnings are not yet established. Converging evidence from neuroimaging, molecular genetics, and psychopharmacology suggests that ISV could index catecholaminergically-mediated neural noise. The fine-grained temporal resolution of electroencephalography is ideal for investigating ISV, but only if potential neural correlates of ISV can be assessed in single trials. Based on evidence that ISV is associated with dopaminergic functioning, we apply a recently developed method of single-trial P3b analysis to investigate the association of COMT Val158Met genotype with measures of ISV on the behavioural and neural levels at different working memory loads. Greater number of Met alleles was associated with poorer and more intra-individually variable performance on the tasks, and greater latency jitter in single-trial P3bs. These converging results at the behavioural and neurophysiological levels confirm previous observations that prefrontal dopamine availability is associated with stability and accuracy of cognitive performance. Together with previous studies, these data imply pleiotropic cognitive effects of COMT genotype.

U2 - 10.1016/j.neuroimage.2014.06.006

DO - 10.1016/j.neuroimage.2014.06.006

M3 - Article

VL - 100

SP - 489

EP - 497

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

ER -