Cyclic guanidine containing amino acids that promote glucocerebrosidase

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Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.

Keywords

  • Cyclic guanidines, Glycosidase inhibitors, Glycosidase promoters, -methylation
Original languageEnglish
Article number132959
JournalTetrahedron
Volume123
DOIs
Publication statusPublished - 24 Sept 2022
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