TY - JOUR

T1 - Double-strand break repair and homologous recombination in Schizosaccharomyces pombe

AU - Raji, Hayatu

AU - Hartsuiker, Edgar

N1 - Copyright 2006 John Wiley & Sons, Ltd.

PY - 2006/10/15

Y1 - 2006/10/15

N2 - The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased its value as a model organism for double-strand break repair. In this review we will focus on the involvement of homologous recombination and repair in different aspects of genome stability in Sz. pombe meiosis, replication and telomere maintenance. We will also discuss anti-recombination pathways (that suppress crossover formation), non-homologous end-joining, single-strand annealing and factors that influence the choice and prevalence of the different repair pathways in Sz. pombe.

AB - The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased its value as a model organism for double-strand break repair. In this review we will focus on the involvement of homologous recombination and repair in different aspects of genome stability in Sz. pombe meiosis, replication and telomere maintenance. We will also discuss anti-recombination pathways (that suppress crossover formation), non-homologous end-joining, single-strand annealing and factors that influence the choice and prevalence of the different repair pathways in Sz. pombe.

KW - DNA Breaks, Double-Stranded

KW - DNA Repair

KW - Genome, Fungal

KW - Mitosis

KW - Recombination, Genetic

KW - Schizosaccharomyces

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1002/yea.1414

DO - 10.1002/yea.1414

M3 - Article

C2 - 17072889

VL - 23

SP - 963

EP - 976

JO - Yeast

JF - Yeast

SN - 0749-503X

IS - 13

ER -