Double-strand break repair and homologous recombination in Schizosaccharomyces pombe
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Yeast, Cyfrol 23, Rhif 13, 15.10.2006, t. 963-76.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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T1 - Double-strand break repair and homologous recombination in Schizosaccharomyces pombe
AU - Raji, Hayatu
AU - Hartsuiker, Edgar
N1 - Copyright 2006 John Wiley & Sons, Ltd.
PY - 2006/10/15
Y1 - 2006/10/15
N2 - The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased its value as a model organism for double-strand break repair. In this review we will focus on the involvement of homologous recombination and repair in different aspects of genome stability in Sz. pombe meiosis, replication and telomere maintenance. We will also discuss anti-recombination pathways (that suppress crossover formation), non-homologous end-joining, single-strand annealing and factors that influence the choice and prevalence of the different repair pathways in Sz. pombe.
AB - The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased its value as a model organism for double-strand break repair. In this review we will focus on the involvement of homologous recombination and repair in different aspects of genome stability in Sz. pombe meiosis, replication and telomere maintenance. We will also discuss anti-recombination pathways (that suppress crossover formation), non-homologous end-joining, single-strand annealing and factors that influence the choice and prevalence of the different repair pathways in Sz. pombe.
KW - DNA Breaks, Double-Stranded
KW - DNA Repair
KW - Genome, Fungal
KW - Mitosis
KW - Recombination, Genetic
KW - Schizosaccharomyces
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1002/yea.1414
DO - 10.1002/yea.1414
M3 - Article
C2 - 17072889
VL - 23
SP - 963
EP - 976
JO - Yeast
JF - Yeast
SN - 0749-503X
IS - 13
ER -