TY - JOUR

T1 - Effects of Home-Based EEG Neurofeedback Training as a Non-Pharmacological Intervention for Parkinson’s Disease

AU - Cooke, Andrew

AU - Hindle, John

AU - Lawrence, Catherine

AU - Bellomo, Eduardo

AU - Pritchard, Aaron W.

AU - MacLeod, Catherine

AU - Martin-Forbes, Pamela

AU - Jones, Sally

AU - Bracewell, Martyn

AU - Linden, David

AU - Mehler, David

N1 - -----Original Message----- From: em.neucli.0.8c045b.94e54b8e@editorialmanager.com <em.neucli.0.8c045b.94e54b8e@editorialmanager.com> On Behalf Of Neurophysiologie Clinique Sent: Wednesday, June 12, 2024 10:26 PM To: Andrew Cooke (Staff) <a.m.cooke@bangor.ac.uk> Subject: Decision on submission to Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) Manuscript Number: NEUCLI-D-24-00044R2   Effects of Home-Based EEG Neurofeedback Training as a Non-Pharmacological Intervention for Parkinson’s Disease   Dear Dr Cooke, Thank you for submitting your manuscript to Neurophysiologie Clinique / Clinical Neurophysiology (NCCN). I am pleased to inform you that your manuscript has been accepted for publication.   Your accepted manuscript will now be transferred to our production department. We will create a proof which you will be asked to check, and you will also be asked to complete a number of online forms required for publication. If we need additional information from you during the production process, we will contact you directly. We appreciate and value your contribution to Neurophysiologie Clinique / Clinical Neurophysiology (NCCN). We regularly invite authors of recently published manuscript to participate in the peer review process. If you were not already part of the journal's reviewer pool, you have now been added to it. We look forward to your continued participation in our journal, and we hope you will consider us again for future submissions. Kind regards,     Aileen McGonigal   Editor-in-Chief Neurophysiologie Clinique / Clinical Neurophysiology (NCCN)

PY - 2024/9

Y1 - 2024/9

N2 - Objectives. Aberrant movement-related cortical activity has been linked to impaired motor function in Parkinson’s disease (PD). Dopaminergic drug treatment can restore these, but dosages and long-term treatment are limited by adverse side-effects. Effective non-pharmacological treatments could help reduce reliance on drugs. This experiment reports the first study of home-based electroencephalographic (EEG) neurofeedback training as a non-pharmacological candidate treatment for PD. Our primary aim was to test the feasibility of our EEG neurofeedback intervention in a home setting.Methods. Sixteen people with PD received six home visits comprising symptomology self-reports, a standardised motor assessment, and a precision handgrip force production task while EEG was recorded (visits 1, 2 and 6); and 3 × 1-hr EEG neurofeedback training sessions to supress the EEG mu rhythm before initiating handgrip movements (visits 3 to 5). Results. Participants successfully learned to self-regulate mu activity, and this appeared to expedite the initiation of precision movements (i.e., time to reach target handgrip force off-medication pre-intervention = 628ms, off-medication post-intervention = 564ms). There was no evidence of wider symptomology reduction (e.g., Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III Motor Examination, off-medication pre-intervention = 29.00, off-medication post intervention = 30.07). Interviews indicated that the intervention was well-received. Conclusion. Based on the significant effect of neurofeedback on movement-related cortical activity, positive qualitative reports from participants, and a suggestive benefit to movement initiation, we conclude that home-based neurofeedback for people with PD is a feasible and promising non-pharmacological treatment that warrants further research.

AB - Objectives. Aberrant movement-related cortical activity has been linked to impaired motor function in Parkinson’s disease (PD). Dopaminergic drug treatment can restore these, but dosages and long-term treatment are limited by adverse side-effects. Effective non-pharmacological treatments could help reduce reliance on drugs. This experiment reports the first study of home-based electroencephalographic (EEG) neurofeedback training as a non-pharmacological candidate treatment for PD. Our primary aim was to test the feasibility of our EEG neurofeedback intervention in a home setting.Methods. Sixteen people with PD received six home visits comprising symptomology self-reports, a standardised motor assessment, and a precision handgrip force production task while EEG was recorded (visits 1, 2 and 6); and 3 × 1-hr EEG neurofeedback training sessions to supress the EEG mu rhythm before initiating handgrip movements (visits 3 to 5). Results. Participants successfully learned to self-regulate mu activity, and this appeared to expedite the initiation of precision movements (i.e., time to reach target handgrip force off-medication pre-intervention = 628ms, off-medication post-intervention = 564ms). There was no evidence of wider symptomology reduction (e.g., Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III Motor Examination, off-medication pre-intervention = 29.00, off-medication post intervention = 30.07). Interviews indicated that the intervention was well-received. Conclusion. Based on the significant effect of neurofeedback on movement-related cortical activity, positive qualitative reports from participants, and a suggestive benefit to movement initiation, we conclude that home-based neurofeedback for people with PD is a feasible and promising non-pharmacological treatment that warrants further research.

U2 - 10.1016/j.neucli.2024.102997

DO - 10.1016/j.neucli.2024.102997

M3 - Article

VL - 54

JO - Neurophysiologie Clinique/Clinical Neurophysiology

JF - Neurophysiologie Clinique/Clinical Neurophysiology

SN - 1769-7131

IS - 5

M1 - 102997

ER -