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Abstract Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, the evidence that adding folate enhances antidepressant treatment is weak. Objectives (1) Estimate the clinical effectiveness and cost-effectiveness of folic acid as adjunct to antidepressant medication (ADM). (2) Explore whether baseline folate and homocysteine predict response to treatment. (3) Investigate whether response to treatment depends on genetic polymorphisms related to folate metabolism.


  • Adult, Antidepressive Agents, Cost-Benefit Analysis, Depression, Female, Folic Acid, Humans, Male, Polymorphism, Genetic, Risk Factors, Treatment Outcome, Wales, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)1-159
JournalHealth Technology Assessment
Issue number48
Publication statusPublished - Jul 2014
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