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Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster

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Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. / Hargreaves, Adam D.; Zhou, Long; Christensen, Josef et al.
In: Proceedings of the National Academy of Sciences of the United States of America: PNAS, Vol. 114, No. 29, 18.07.2017, p. 7677–7682.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Hargreaves, AD, Zhou, L, Christensen, J, Marletaz, F, Liu, S, Li, F, Jansen, PG, Spiga, E, Hansen, MT, Pedersen, SVH, Biswas, S, Seriwaka, K, Fox, BA, Taylor, WR, Mulley, J, Zhang, G, Heller, RS & Holland, PWH 2017, 'Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster', Proceedings of the National Academy of Sciences of the United States of America: PNAS, vol. 114, no. 29, pp. 7677–7682. https://doi.org/10.1073/pnas.1702930114

APA

Hargreaves, A. D., Zhou, L., Christensen, J., Marletaz, F., Liu, S., Li, F., Jansen, P. G., Spiga, E., Hansen, M. T., Pedersen, S. V. H., Biswas, S., Seriwaka, K., Fox, B. A., Taylor, W. R., Mulley, J., Zhang, G., Heller, R. S., & Holland, P. W. H. (2017). Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. Proceedings of the National Academy of Sciences of the United States of America: PNAS, 114(29), 7677–7682. https://doi.org/10.1073/pnas.1702930114

CBE

Hargreaves AD, Zhou L, Christensen J, Marletaz F, Liu S, Li F, Jansen PG, Spiga E, Hansen MT, Pedersen SVH, et al. 2017. Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. Proceedings of the National Academy of Sciences of the United States of America: PNAS. 114(29):7677–7682. https://doi.org/10.1073/pnas.1702930114

MLA

Hargreaves, Adam D. et al. "Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster". Proceedings of the National Academy of Sciences of the United States of America: PNAS. 2017, 114(29). 7677–7682. https://doi.org/10.1073/pnas.1702930114

VancouverVancouver

Hargreaves AD, Zhou L, Christensen J, Marletaz F, Liu S, Li F et al. Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. Proceedings of the National Academy of Sciences of the United States of America: PNAS. 2017 Jul 18;114(29):7677–7682. Epub 2017 Jul 3. doi: 10.1073/pnas.1702930114

Author

Hargreaves, Adam D. ; Zhou, Long ; Christensen, Josef et al. / Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. In: Proceedings of the National Academy of Sciences of the United States of America: PNAS. 2017 ; Vol. 114, No. 29. pp. 7677–7682.

RIS

TY - JOUR

T1 - Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster

AU - Hargreaves, Adam D.

AU - Zhou, Long

AU - Christensen, Josef

AU - Marletaz, Ferdinand

AU - Liu, Shiping

AU - Li, Fang

AU - Jansen, Peter Gildsig

AU - Spiga, Enrico

AU - Hansen, Matilde Thye

AU - Pedersen, Signe Vendelbo Horn

AU - Biswas, Shameek

AU - Seriwaka, Kyle

AU - Fox, Brian A.

AU - Taylor, William R.

AU - Mulley, John

AU - Zhang, Guojie

AU - Heller, R. Scott

AU - Holland, Peter W. H.

PY - 2017/7/18

Y1 - 2017/7/18

N2 - The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.

AB - The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.

UR - https://www.pnas.org/content/114/29/7677/tab-figures-data

U2 - 10.1073/pnas.1702930114

DO - 10.1073/pnas.1702930114

M3 - Article

VL - 114

SP - 7677

EP - 7682

JO - Proceedings of the National Academy of Sciences of the United States of America: PNAS

JF - Proceedings of the National Academy of Sciences of the United States of America: PNAS

SN - 0027-8424

IS - 29

ER -