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  • Gordon McGregor
    University Hospital, Coventry
  • Simon Nichols
    University of Hull
  • Thomas Hamborg
    University of Warwick
  • Lucy Bryning
  • Rhiannon Edwards
  • David Markland
  • Jenny Mercer
    Cardiff Metropolitan University
  • Stefan Birkett
    University of Hull
  • Stewart Ennis
    University Hospital, Coventry
  • Richard Powell
    University Hospital, Coventry
  • Brian Begg
    Cardiff Metropolitan University
  • Mark Haykowsky
    University of Texas, Arlington
  • Prithwish Banerjee
    University Hospital, Coventry
  • Lee Ingle
    University of Hull
  • Rob Shave
    Cardiff Metropolitan University
  • Karianne Backx
    Cardiff Metropolitan University
Current international guidelines for cardiac rehabilitation (CR) advocate moderate-intensity exercise training (MISS, moderate-intensity steady state). This recommendation predates significant advances in medical therapy for coronary heart disease (CHD) and may not be the most appropriate strategy for the ‘modern’ patient with CHD. High-intensity interval training (HIIT) appears to be a safe and effective alternative, resulting in greater improvements in peak oxygen uptake (VO2 peak). To date, HIIT trials have predominantly been proof-of-concept studies in the laboratory setting and conducted outside the UK. The purpose of this multicentre randomised controlled trial is to compare the effects of HIIT and MISS training in patients with CHD attending UK CR programmes.


  • High intensity interval training; HIIT; cardiac rehabilitation
Original languageEnglish
Article number6:e012843
Pages (from-to)1-9
Number of pages9
JournalBMJ Open
Issue number11
Publication statusPublished - 18 Nov 2016

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