Identification of youth at clinical high-risk for psychosis: A community-based study from India.

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  • Identification of youth at clinical high-risk for psychosis- A community-based study

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  • Sai Krishna Tikka
    All India Institute of Medical Sciences (AIIMS) New Delhi
  • Barikar C. Malathesh
    All India Institute of Medical Sciences (AIIMS) New Delhi
  • Mamidipalli Sai Spoorthy
    All India Institute of Medical Sciences (AIIMS) New Delhi
  • Govindrao N. Kusneniwar
    All India Institute of Medical Sciences (AIIMS) New Delhi
  • Neeraj Agarwal
    All India Institute of Medical Sciences (AIIMS) New Delhi
  • Giovanni D Avossa
  • Mohammad Zia Ul Haq Katshu
    University of Nottingham
Aim: A two-stage process, wherein self-report screening precedes the structured
interview, is suggested for identifying individuals at clinical high-risk for psychosis (CHR-P) in community samples. Aim of this study was to screen a community youth sample from India for CHR-P using the two-stage method. Specific objectives were to assess concordant validity of the self-report measure and predictive validity of the two-stage method.
Methods: Based on probability sampling, 2025 youth aged 15–24 years were
recruited from one rural and one urban area of Telangana, a Telugu-speaking state in India. Telugu version of the PRIME Screen-Revised (PS-R) and structured interview for psychosis-risk syndromes (SIPS) were used. CHR-P positive and negative cohorts were followed-up for transition to psychosis at 3-monthly intervals.
Results: One hundred ten individuals screened positive on PS-R. SIPS conducted on 67 out of 110 individuals confirmed 62 (92.54%) to be CHR-P positive. PS-R showed 98.41% sensitivity and 90.74% specificity. Among CHR-P positive, three participants transitioned to psychosis in 15 months. The hazard ratio for psychosis transition was 11.4.
Conclusions: Screening accuracy of PS-R in the community youth sample in Telangana is optimum. The hazard ratio for psychosis transition in the community identified CHR-P indicates good predictive validity for the two-stage method.

Keywords

  • psychosis, Epidemiology
Original languageEnglish
Number of pages11
JournalEarly Intervention in Psychiatry
Early online date28 May 2024
DOIs
Publication statusE-pub ahead of print - 28 May 2024
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