Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study
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DOI
Ischaemic preconditioning in rats was studied using MRI. Ischaemic preconditioning was induced, using an intraluminal filament method, by 30 min middle cerebral artery occlusion (MCAO), and imaged 24 h later. The secondary insult of 100 min MCAO was induced 3 days following preconditioning and imaged 24 and 72 h later. Twenty-four hours following ischaemic preconditioning most rats showed small sub-cortical hyperintense regions not seen in sham-preconditioned rats. Twenty-four hours and 72 h following the secondary insult preconditioned animals showed significantly smaller lesions (24 h = 112 +/- 31 mm(3), mean +/- standard error; 72 h = 80 +/- 35 mm(3)), which were confined to the striatum, than controls (24 h = 234 +/- 32 mm(3), p = 0.026; 72 h = 275 +/- 37 mm(3), p = 0.003). In addition during lesion maturation from 24 to 72 h post-secondary MCAO, preconditioned rats displayed an average reduction in lesion size as measured by MRI whereas sham-preconditioned rats displayed increases in lesion size; this is the first report of such differential lesion volume evolution in cerebral ischaemic preconditioning.
Keywords
- Animals, Ischemic Attack, Transient, Ischemic Preconditioning, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Cerebral Artery, Rats, Rats, Sprague-Dawley, Journal Article, Research Support, Non-U.S. Gov't
Original language | English |
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Pages (from-to) | 204-209 |
Number of pages | 6 |
Journal | NMR in biomedicine |
Volume | 14 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 2001 |
Prof. activities and awards (1)
Headway North Wales Conference
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