Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study

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Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study. / Mullins, P G; Reid, D G; Hockings, P D et al.
In: NMR in biomedicine, Vol. 14, No. 3, 05.2001, p. 204-209.

Research output: Contribution to journalArticlepeer-review

HarvardHarvard

Mullins, PG, Reid, DG, Hockings, PD, Hadingham, SJ, Campbell, CA, Chalk, JB & Doddrell, DM 2001, 'Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study', NMR in biomedicine, vol. 14, no. 3, pp. 204-209. https://doi.org/10.1002/nbm.703

APA

Mullins, P. G., Reid, D. G., Hockings, P. D., Hadingham, S. J., Campbell, C. A., Chalk, J. B., & Doddrell, D. M. (2001). Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study. NMR in biomedicine, 14(3), 204-209. https://doi.org/10.1002/nbm.703

CBE

Mullins PG, Reid DG, Hockings PD, Hadingham SJ, Campbell CA, Chalk JB, Doddrell DM. 2001. Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study. NMR in biomedicine. 14(3):204-209. https://doi.org/10.1002/nbm.703

MLA

VancouverVancouver

Mullins PG, Reid DG, Hockings PD, Hadingham SJ, Campbell CA, Chalk JB et al. Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study. NMR in biomedicine. 2001 May;14(3):204-209. doi: 10.1002/nbm.703

Author

Mullins, P G ; Reid, D G ; Hockings, P D et al. / Ischaemic preconditioning in the rat brain : a longitudinal magnetic resonance imaging (MRI) study. In: NMR in biomedicine. 2001 ; Vol. 14, No. 3. pp. 204-209.

RIS

TY - JOUR

T1 - Ischaemic preconditioning in the rat brain

T2 - a longitudinal magnetic resonance imaging (MRI) study

AU - Mullins, P G

AU - Reid, D G

AU - Hockings, P D

AU - Hadingham, S J

AU - Campbell, C A

AU - Chalk, J B

AU - Doddrell, D M

N1 - Copyright -Copyright 2001 John Wiley & Sons, Ltd.

PY - 2001/5

Y1 - 2001/5

N2 - Ischaemic preconditioning in rats was studied using MRI. Ischaemic preconditioning was induced, using an intraluminal filament method, by 30 min middle cerebral artery occlusion (MCAO), and imaged 24 h later. The secondary insult of 100 min MCAO was induced 3 days following preconditioning and imaged 24 and 72 h later. Twenty-four hours following ischaemic preconditioning most rats showed small sub-cortical hyperintense regions not seen in sham-preconditioned rats. Twenty-four hours and 72 h following the secondary insult preconditioned animals showed significantly smaller lesions (24 h = 112 +/- 31 mm(3), mean +/- standard error; 72 h = 80 +/- 35 mm(3)), which were confined to the striatum, than controls (24 h = 234 +/- 32 mm(3), p = 0.026; 72 h = 275 +/- 37 mm(3), p = 0.003). In addition during lesion maturation from 24 to 72 h post-secondary MCAO, preconditioned rats displayed an average reduction in lesion size as measured by MRI whereas sham-preconditioned rats displayed increases in lesion size; this is the first report of such differential lesion volume evolution in cerebral ischaemic preconditioning.

AB - Ischaemic preconditioning in rats was studied using MRI. Ischaemic preconditioning was induced, using an intraluminal filament method, by 30 min middle cerebral artery occlusion (MCAO), and imaged 24 h later. The secondary insult of 100 min MCAO was induced 3 days following preconditioning and imaged 24 and 72 h later. Twenty-four hours following ischaemic preconditioning most rats showed small sub-cortical hyperintense regions not seen in sham-preconditioned rats. Twenty-four hours and 72 h following the secondary insult preconditioned animals showed significantly smaller lesions (24 h = 112 +/- 31 mm(3), mean +/- standard error; 72 h = 80 +/- 35 mm(3)), which were confined to the striatum, than controls (24 h = 234 +/- 32 mm(3), p = 0.026; 72 h = 275 +/- 37 mm(3), p = 0.003). In addition during lesion maturation from 24 to 72 h post-secondary MCAO, preconditioned rats displayed an average reduction in lesion size as measured by MRI whereas sham-preconditioned rats displayed increases in lesion size; this is the first report of such differential lesion volume evolution in cerebral ischaemic preconditioning.

KW - Animals

KW - Ischemic Attack, Transient

KW - Ischemic Preconditioning

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Cerebral Artery

KW - Rats

KW - Rats, Sprague-Dawley

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/nbm.703

DO - 10.1002/nbm.703

M3 - Article

C2 - 11357186

VL - 14

SP - 204

EP - 209

JO - NMR in biomedicine

JF - NMR in biomedicine

SN - 0952-3480

IS - 3

ER -