Longer Duration of Untreated Psychosis is associated with poorer outcomes for patients with Delusional Infestation
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In: Acta Dermato-Venereologica, Vol. 98, No. 9, 09.2018, p. 848-854.
Research output: Contribution to journal › Article › peer-review
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T1 - Longer Duration of Untreated Psychosis is associated with poorer outcomes for patients with Delusional Infestation
AU - Romanov, Dimitry
AU - Lepping, Peter
AU - Bewley, Anthony
AU - Huber, Markus
AU - Freudenmann, Roland W.
AU - Lvov, Andrey
AU - Bertel Squire, Stephen
AU - Noorthoorn, Eric O.
PY - 2018/9
Y1 - 2018/9
N2 - We examined the association between the duration of untreated psychosis (DUP) and outcome for patients with delusional infestation (DI). This multi-centre international study included consecutive 211 patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at base line and follow-up. A regression analysis showed a clear clinical and statistically significant association between shorter duration of untreated psychosis and better outcome at follow up. Patients with a DUP of less than 1 year showed a CGI-S change from 5.37 to 2.07; those with a DUP of 1-5 years a change from 5.48 to 2.59, and those with a DUP of above 5 years a change from 5.59 to 3.37. This difference of 1.1 CGI points between the groups resembles a clinically relevant difference in patient outcome Our results suggest that longer duration of untreated psychosis in patients with DI is associated with significantly less favourable clinical outcomes.
AB - We examined the association between the duration of untreated psychosis (DUP) and outcome for patients with delusional infestation (DI). This multi-centre international study included consecutive 211 patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at base line and follow-up. A regression analysis showed a clear clinical and statistically significant association between shorter duration of untreated psychosis and better outcome at follow up. Patients with a DUP of less than 1 year showed a CGI-S change from 5.37 to 2.07; those with a DUP of 1-5 years a change from 5.48 to 2.59, and those with a DUP of above 5 years a change from 5.59 to 3.37. This difference of 1.1 CGI points between the groups resembles a clinically relevant difference in patient outcome Our results suggest that longer duration of untreated psychosis in patients with DI is associated with significantly less favourable clinical outcomes.
U2 - 10.2340/00015555-2888
DO - 10.2340/00015555-2888
M3 - Article
VL - 98
SP - 848
EP - 854
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 9
ER -