Standard Standard

Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease. / Harcourt, Jonny P; Lambert, Aileen; Wong, Phui Yee et al.
In: Otology and Neurotology, Vol. 40, No. 4, 07.02.2019, p. 491-496.

Research output: Contribution to journalArticlepeer-review

HarvardHarvard

Harcourt, JP, Lambert, A, Wong, PY, Patel, M, Agarwal, K, Golding, JF & Bronstein, AM 2019, 'Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease', Otology and Neurotology, vol. 40, no. 4, pp. 491-496.

APA

Harcourt, J. P., Lambert, A., Wong, P. Y., Patel, M., Agarwal, K., Golding, J. F., & Bronstein, A. M. (2019). Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease. Otology and Neurotology, 40(4), 491-496. Advance online publication.

CBE

Harcourt JP, Lambert A, Wong PY, Patel M, Agarwal K, Golding JF, Bronstein AM. 2019. Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease. Otology and Neurotology. 40(4):491-496.

MLA

VancouverVancouver

Harcourt JP, Lambert A, Wong PY, Patel M, Agarwal K, Golding JF et al. Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease. Otology and Neurotology. 2019 Feb 7;40(4):491-496. Epub 2019 Feb 7.

Author

Harcourt, Jonny P ; Lambert, Aileen ; Wong, Phui Yee et al. / Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease. In: Otology and Neurotology. 2019 ; Vol. 40, No. 4. pp. 491-496.

RIS

TY - JOUR

T1 - Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menie`re’s Disease

AU - Harcourt, Jonny P

AU - Lambert, Aileen

AU - Wong, Phui Yee

AU - Patel, Mitesh

AU - Agarwal, Kiran

AU - Golding, John F

AU - Bronstein, Adolfo M

PY - 2019/2/7

Y1 - 2019/2/7

N2 - Objectives: To determine whether long term (>48 months) symptomatic vertigo control is sustained in patients with Menière’s disease from a previous comparative trial of intratympanic methylprednisolone versus gentamicin, and if the two treatments remain nonsignificantly different at longterm follow-up. Study Design: Mail survey recording vertigo frequency in the previous one and six months, further intratympanic treatment received, and validated symptom questionnaires. Setting: Outpatient hospital clinic setting. Patients: Adult patients with definite unilateral refractory Menie`re’s disease, who previously received in tratympanic treatment in a comparative trial. Intervention: A survey of trial participants who received intratympanic gentamicin (40 mg/mL) or methylprednisolone (62.5 mg/mL). Outcome measures: Primary: number of vertigo attacks in the 6 months prior to receiving this survey compared with the 6 months before the first trial injection. Secondary: : Number of vertigo attacks over the previous 1 month; validated symptom questionnaire scores of tinnitus, dizziness, vertigo, aural fullness, and functional disability. Results: Average follow-up was 70.8 months (standard deviation 17.0) from the first treatment injection. Vertigo attacks in the 6 months prior to receiving the current survey reduced by 95% compared to baseline in both drug groups (intention-to-treat analysis, both p<0.001). No significant difference between drugs was found for the primary and secondary outcomes. Eight participants (methylprednisolone ¼ 5 and gentamicin ¼ 3) required further injections for relapse after completing the original trial. Conclusion: Intratympanic methylprednisolone treatment provides effective long-lasting relief of vertigo, without the known inner-ear toxicity associated with gentamicin. There are no significant differences between the two treatments at long term follow-up.

AB - Objectives: To determine whether long term (>48 months) symptomatic vertigo control is sustained in patients with Menière’s disease from a previous comparative trial of intratympanic methylprednisolone versus gentamicin, and if the two treatments remain nonsignificantly different at longterm follow-up. Study Design: Mail survey recording vertigo frequency in the previous one and six months, further intratympanic treatment received, and validated symptom questionnaires. Setting: Outpatient hospital clinic setting. Patients: Adult patients with definite unilateral refractory Menie`re’s disease, who previously received in tratympanic treatment in a comparative trial. Intervention: A survey of trial participants who received intratympanic gentamicin (40 mg/mL) or methylprednisolone (62.5 mg/mL). Outcome measures: Primary: number of vertigo attacks in the 6 months prior to receiving this survey compared with the 6 months before the first trial injection. Secondary: : Number of vertigo attacks over the previous 1 month; validated symptom questionnaire scores of tinnitus, dizziness, vertigo, aural fullness, and functional disability. Results: Average follow-up was 70.8 months (standard deviation 17.0) from the first treatment injection. Vertigo attacks in the 6 months prior to receiving the current survey reduced by 95% compared to baseline in both drug groups (intention-to-treat analysis, both p<0.001). No significant difference between drugs was found for the primary and secondary outcomes. Eight participants (methylprednisolone ¼ 5 and gentamicin ¼ 3) required further injections for relapse after completing the original trial. Conclusion: Intratympanic methylprednisolone treatment provides effective long-lasting relief of vertigo, without the known inner-ear toxicity associated with gentamicin. There are no significant differences between the two treatments at long term follow-up.

M3 - Article

VL - 40

SP - 491

EP - 496

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 4

ER -