Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway
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DOI
Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.
| Original language | English |
|---|---|
| Pages (from-to) | 20744-20751 |
| Journal | RSC Advances |
| Volume | 4 |
| Issue number | 40 |
| DOIs | |
| Publication status | Published - 28 Apr 2014 |