Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway
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In: RSC Advances, Vol. 4, No. 40, 28.04.2014, p. 20744-20751.
Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway
AU - Murphy, P.J.
AU - Evans, D.M.
AU - Horton, P.N.
AU - Hursthouse, M.B.
PY - 2014/4/28
Y1 - 2014/4/28
N2 - Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.
AB - Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.
U2 - 10.1039/C4RA03031A
DO - 10.1039/C4RA03031A
M3 - Article
VL - 4
SP - 20744
EP - 20751
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 40
ER -