Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium
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Steroidal and triterpenoid saponins are attractive for their wide‐ranging pharmacological properties. The triterpenoid saponins Anemoclemoside A and B are root constituents of the Chinese folk medicinal plant Anemoclema glaucifolium (Ranunculaceae). Both compounds feature an unusual cyclic acetal linkage to the carbohydrate L‐arabinose in its open chain form rather than the typical glycosidic bond present in normal saponins. The straightforward and scalable syntheses of both saponins starting from L‐arabinose as well as L‐lyxose and L‐rhamnose are described.
Keywords
- Anemoclemosides, Cyclic acetal glycosidic linkage, Glycosylation, Hederagenin glycosides, Saponins
| Original language | English |
|---|---|
| Pages (from-to) | 7470-7473 |
| Journal | European Journal of Organic Chemistry |
| Volume | 2020 |
| Issue number | 48 |
| Early online date | 19 Oct 2020 |
| DOIs | |
| Publication status | Published - 31 Dec 2020 |
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