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Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium

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Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium. / Bouillon, Marc; Bertocco, Katia; Bischoff, Laura et al.
In: European Journal of Organic Chemistry, Vol. 2020, No. 48, 31.12.2020, p. 7470-7473.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Bouillon, M, Bertocco, K, Bischoff, L, Buri, M, Davies, LR, Wilkinson, EJ & Lahmann, M 2020, 'Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium', European Journal of Organic Chemistry, vol. 2020, no. 48, pp. 7470-7473. https://doi.org/10.1002/ejoc.202001317

APA

Bouillon, M., Bertocco, K., Bischoff, L., Buri, M., Davies, L. R., Wilkinson, E. J., & Lahmann, M. (2020). Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium. European Journal of Organic Chemistry, 2020(48), 7470-7473. https://doi.org/10.1002/ejoc.202001317

CBE

Bouillon M, Bertocco K, Bischoff L, Buri M, Davies LR, Wilkinson EJ, Lahmann M. 2020. Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium. European Journal of Organic Chemistry. 2020(48):7470-7473. https://doi.org/10.1002/ejoc.202001317

MLA

Bouillon, Marc et al. "Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium". European Journal of Organic Chemistry. 2020, 2020(48). 7470-7473. https://doi.org/10.1002/ejoc.202001317

VancouverVancouver

Bouillon M, Bertocco K, Bischoff L, Buri M, Davies LR, Wilkinson EJ et al. Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium. European Journal of Organic Chemistry. 2020 Dec 31;2020(48):7470-7473. Epub 2020 Oct 19. doi: 10.1002/ejoc.202001317

Author

Bouillon, Marc ; Bertocco, Katia ; Bischoff, Laura et al. / Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium. In: European Journal of Organic Chemistry. 2020 ; Vol. 2020, No. 48. pp. 7470-7473.

RIS

TY - JOUR

T1 - Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium

AU - Bouillon, Marc

AU - Bertocco, Katia

AU - Bischoff, Laura

AU - Buri, Michelle

AU - Davies, lucy Rebecca

AU - Wilkinson, Elizabeth Jane

AU - Lahmann, Martina

N1 - Innovate UK. Grant Number: 102101 BEACON Biorefining Centre of Excellence Innovate UK. Grant Number: 101091

PY - 2020/12/31

Y1 - 2020/12/31

N2 - Steroidal and triterpenoid saponins are attractive for their wide‐ranging pharmacological properties. The triterpenoid saponins Anemoclemoside A and B are root constituents of the Chinese folk medicinal plant Anemoclema glaucifolium (Ranunculaceae). Both compounds feature an unusual cyclic acetal linkage to the carbohydrate L‐arabinose in its open chain form rather than the typical glycosidic bond present in normal saponins. The straightforward and scalable syntheses of both saponins starting from L‐arabinose as well as L‐lyxose and L‐rhamnose are described.

AB - Steroidal and triterpenoid saponins are attractive for their wide‐ranging pharmacological properties. The triterpenoid saponins Anemoclemoside A and B are root constituents of the Chinese folk medicinal plant Anemoclema glaucifolium (Ranunculaceae). Both compounds feature an unusual cyclic acetal linkage to the carbohydrate L‐arabinose in its open chain form rather than the typical glycosidic bond present in normal saponins. The straightforward and scalable syntheses of both saponins starting from L‐arabinose as well as L‐lyxose and L‐rhamnose are described.

KW - Anemoclemosides

KW - Cyclic acetal glycosidic linkage

KW - Glycosylation

KW - Hederagenin glycosides

KW - Saponins

U2 - 10.1002/ejoc.202001317

DO - 10.1002/ejoc.202001317

M3 - Article

VL - 2020

SP - 7470

EP - 7473

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

SN - 1434-193X

IS - 48

ER -