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Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity

Research output: Contribution to journal › Article › peer-review

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Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. / Cartmell, Christopher ; Evans, Daniel; Elwood, Jessica ML et al.
In: Toxicology in Vitro, Vol. 44, 10.2017, p. 172-181.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Cartmell, C, Evans, D, Elwood, JML, Fituri, H, Murphy, P, Caspari, T, Poniedziałekc, B & Rzymskic, P 2017, 'Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity', Toxicology in Vitro, vol. 44, pp. 172-181. https://doi.org/10.1016/j.tiv.2017.07.007

APA

Cartmell, C., Evans, D., Elwood, J. ML., Fituri, H., Murphy, P., Caspari, T., Poniedziałekc, B., & Rzymskic, P. (2017). Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. Toxicology in Vitro, 44, 172-181. https://doi.org/10.1016/j.tiv.2017.07.007

CBE

Cartmell C, Evans D, Elwood JML, Fituri H, Murphy P, Caspari T, Poniedziałekc B, Rzymskic P. 2017. Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. Toxicology in Vitro. 44:172-181. https://doi.org/10.1016/j.tiv.2017.07.007

MLA

Cartmell, Christopher et al. "Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity". Toxicology in Vitro. 2017, 44. 172-181. https://doi.org/10.1016/j.tiv.2017.07.007

VancouverVancouver

Cartmell C, Evans D, Elwood JML, Fituri H, Murphy P, Caspari T et al. Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. Toxicology in Vitro. 2017 Oct;44:172-181. Epub 2017 Jul 10. doi: 10.1016/j.tiv.2017.07.007

Author

Cartmell, Christopher ; Evans, Daniel ; Elwood, Jessica ML et al. / Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. In: Toxicology in Vitro. 2017 ; Vol. 44. pp. 172-181.

RIS

TY - JOUR

T1 - Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity

AU - Cartmell, Christopher

AU - Evans, Daniel

AU - Elwood, Jessica ML

AU - Fituri, Hisham

AU - Murphy, Patrick

AU - Caspari, Thomas

AU - Poniedziałekc, Barbara

AU - Rzymskic, Piotr

PY - 2017/10

Y1 - 2017/10

N2 - Highlights•The role of the C7-OH group in the activity of cylindrospermopsin 1 is unknown.•Synthetic analogues (11a–c) of cylindrospermopsin 1 were prepared.•Toxicity of these analogues was compared with 1 using human neutrophils in vitro.•The greatest toxicity was found in 11c with a 6-carbon tether and an –OH group.•An analogue closely resembling 1 but lacking the C7-OH group had low toxicity.

AB - Highlights•The role of the C7-OH group in the activity of cylindrospermopsin 1 is unknown.•Synthetic analogues (11a–c) of cylindrospermopsin 1 were prepared.•Toxicity of these analogues was compared with 1 using human neutrophils in vitro.•The greatest toxicity was found in 11c with a 6-carbon tether and an –OH group.•An analogue closely resembling 1 but lacking the C7-OH group had low toxicity.

KW - Cylindrospermopsin;

KW - Guanidine synthesis

KW - Neutrophils

KW - Oxidative stress

KW - Reactive oxygen species

KW - Superoxide dismutase

KW - Catalase

KW - Glutathione peroxidase

U2 - 10.1016/j.tiv.2017.07.007

DO - 10.1016/j.tiv.2017.07.007

M3 - Article

VL - 44

SP - 172

EP - 181

JO - Toxicology in Vitro

JF - Toxicology in Vitro

SN - 0887-2333

ER -