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DOI

  • Holly Robson
    University of Manchester
  • Roland Zahn
    University of Manchester
  • James Keidel
  • Richard J Binney
    University of Manchester
  • Karen Sage
    University of Manchester
  • Matthew Lambon Ralph
    University of Manchester

Wernicke's aphasia occurs after a stroke to classical language comprehension regions in the left temporoparietal cortex. Consequently, auditory-verbal comprehension is significantly impaired in Wernicke's aphasia but the capacity to comprehend visually presented materials (written words and pictures) is partially spared. This study used functional magnetic resonance imaging to investigate the neural basis of written word and picture semantic processing in Wernicke's aphasia, with the wider aim of examining how the semantic system is altered after damage to the classical comprehension regions. Twelve participants with chronic Wernicke's aphasia and 12 control participants performed semantic animate-inanimate judgements and a visual height judgement baseline task. Whole brain and region of interest analysis in Wernicke's aphasia and control participants found that semantic judgements were underpinned by activation in the ventral and anterior temporal lobes bilaterally. The Wernicke's aphasia group displayed an 'over-activation' in comparison with control participants, indicating that anterior temporal lobe regions become increasingly influential following reduction in posterior semantic resources. Semantic processing of written words in Wernicke's aphasia was additionally supported by recruitment of the right anterior superior temporal lobe, a region previously associated with recovery from auditory-verbal comprehension impairments. Overall, the results provide support for models in which the anterior temporal lobes are crucial for multimodal semantic processing and that these regions may be accessed without support from classic posterior comprehension regions.

Keywords

  • Wernicke’s aphasia, Wernicke’s area, anterior temporal lobe, language comprehension, semantic processing
Original languageEnglish
Pages (from-to)931-43
Number of pages13
JournalBrain: A journal of Neurology
Volume137
Issue number3
DOIs
Publication statusPublished - 1 Mar 2014
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