The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues.
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DOI
(11R, 12S)-lactobacillic acid (1) has been prepared either from D-mannitol by asymmetric cyclopropanation or from cycyclopropane-1, 2-dimethanol by enzymatic desymmetrisation. The syntheses of (11S, 12R)-lactobacillic acid (2) and (1R, 2S) 1(3'-methoxycarbonylpropyl)-2-octadecylcopropane (26) and related analogues (27 and 28) have also been achieved. (C) 1999 Elsevier Science Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 6689-6692 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 40 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 3 Sept 1999 |