The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters
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Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.
| Original language | English |
|---|---|
| Pages (from-to) | 7143-7158 |
| Number of pages | 15 |
| Journal | Tetrahedron |
| Volume | 72 |
| Issue number | 45 |
| Early online date | 14 Sept 2016 |
| DOIs | |
| Publication status | Published - 10 Nov 2016 |
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