The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters
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In: Tetrahedron, Vol. 72, No. 45, 10.11.2016, p. 7143-7158.
Research output: Contribution to journal › Article › peer-review
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T1 - The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters
AU - Ali, Hanan
AU - Koza, Gani
AU - Hameed, Rwoaa
AU - Rowles, Richard
AU - Davies, Carys
AU - Al-Dulayymi, Juma'a R.
AU - Gwenin, Christopher
AU - Baird, Mark
PY - 2016/11/10
Y1 - 2016/11/10
N2 - Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.
AB - Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.
U2 - 10.1016/j.tet.2016.08.089
DO - 10.1016/j.tet.2016.08.089
M3 - Article
VL - 72
SP - 7143
EP - 7158
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 45
ER -