This article reports on the use of the card-based game method in semi-structured interviews in three separate research projects. The essence of the method is simple: cards are created with words or images to represent the concepts or terms that are central to the topics in a semi-structured interview; the cards then act as visual cues to facilitate focus and prompt reflection. Of greater interest is the application of the approach in specific contexts, and the benefits that accrue from its application. This research demonstrates that the card game method can be used to provide qualitative validation of theoretical models, and can be applied variously to elicit and explore definitions, priorities, processes, challenges, issues, difficulties, views on the future and critical success factors. The card game method and other innovative techniques that involve the interviewee in activities have the potential to enhance the value of semi-structured interviews.