Electronic versions

Documents

DOI

  • Tirso RJ Gonzalez Alam
  • Katya Krieger-Redwood
    York University
  • Dominika Varga
    University of Sussex
  • Zhiyao Gao
    Stanford University
  • Aidan Horner
    University of York
  • Tom Hartley
    University of York
  • Michel Thiebaut de Schotten
    Université Bordeaux
  • Magdalena W Sliwinska
    Liverpool John Moores University
  • David Pitcher
    University of York
  • Daniel S. Margulies
    Centre National de la Recherche Scientifique (CNRS)
  • Jonathan Smallwood
    Queens's University, Kingston, Canada
  • Elizabeth Jefferies
    York University
Processing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually-mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. Participants learned virtual environments consisting of buildings populated with objects, drawn from either a single semantic category or multiple categories. Later, they made semantic and spatial context decisions about these objects and buildings during functional magnetic resonance imaging. A lateral ventral occipital to frontotemporal DMN pathway was primarily engaged by semantic judgements, while a medial visual to medial temporal DMN pathway supported spatial context judgements. These pathways had distinctive locations in functional connectivity space: the semantic pathway was both further from unimodal systems and more balanced between visual and auditory-motor regions compared with the spatial pathway. When semantic and spatial context information could be integrated (in buildings containing objects from a single category), regions at the intersection of these pathways responded, suggesting that parallel processing streams interact at multiple levels of the cortical hierarchy to produce coherent memory-guided cognition.
Original languageEnglish
Volume1
DOIs
Publication statusPublished - 17 Apr 2023

Publication series

NameElife
PublishereLife Sciences Publications
ISSN (Print)2050-084X

Total downloads

No data available
View graph of relations