Professor Alexander Yakunin
Professor In Enzyme Discovery and Application
Contact info
Professor Alexander Yakunin (Iakounine)
Office: Thoday Building, room S25
Email: a.iakounine@bangor.ac.uk
Tel: 01248 388399
Research focus: enzyme discovery, enzymology, enzyme applications
- 2024
- E-gyhoeddi cyn argraffu
Ni(II)-binding affinity of CcNikZ-II and its homologs: the role of the HH-prong and variable loop revealed by structural and mutational studies
Diep, P., Stogios, P. J., Evdokimova, E., Savchenko, A., Mahadevan, R. & Yakunin, A. F., 31 Maw 2024, (E-gyhoeddi cyn argraffu) Yn: Febs Journal.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2023
- Cyhoeddwyd
One-pot chemo-enzymatic synthesis and one-step recovery of length-variable long-chain polyphosphates from microalgal biomass
Lin, Y-H., Nishikawa, S., Jia, T. Z., Yeh, F-I., Khusnutdinova, A., Yakunin, A., Fujishima, K. & Wang, P-H., 27 Hyd 2023, Yn: Green Chemistry. 23Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases
Khusnutdinova, A. N., Batyrova, K., Brown, G., Fedorchuck, T., Chai, Y. S., Skarina, T., Flick, R., Petit, A-P., Savchenko, A., Stogios, P. & Yakunin, A., Hyd 2023, Yn: Febs Journal. 290, 20, t. 4966-4983 18 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling
Williams, G., Ma, H., Khusnutdinova, A., Yakunin, A. & Golyshin, P., Awst 2023, Yn: Essays in Biochemistry. 67, 4, t. 715-729 15 t., EBC20220255.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid
- Cyhoeddwyd
CRISPR-induced DNA reorganization for multiplexed nucleic acid detection
Karlikow, M., Amalfitano, E., Yang, X., Doucet, J., Chapman, A., Sadat-Moussavi, P., Homme, P., Sutyrina, P., Chang, W., Lemak, S., Yakunin, A., Dolezal, A. G., Kelley, S., Foster, L., Harpur, B. & Pardee, K., 17 Maw 2023, Yn: Nature Communications. 14, 1, 1505.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Thermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins
Distaso, M., Chernikova, T., Bargiela, R., Coscolín, C., Stogios, P. J., Gonzalez-Alfonso, J. L., Lemak, S., Khusnutdinova, A., Plou, F. J., Evdokimova, E., Savchenko, A., Lunev, E., Yakimov, M. M., Golyshina, O., Ferrer, M., Yakunin, A. & Golyshin, P., 28 Chwef 2023, Yn: Applied and Environmental Microbiology. 89, 2, t. e0170422 20 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2022
- Cyhoeddwyd
Metabolite Damage and Damage-Control in a Minimal Genome
Haas, D., Thamm, A. M., Sun, J., Huang, L., Sun, L., Beaudoin, G. A. W., Wise, K. S., Lema-Ortiz, C., Bruner, S. D., Breuer, M., Luthey-Schutten, Z., Lin, J., Wilson, M. A., Brown, G., Yakunin, A., Kurilyak, I., Folz, J., Fiehn, O., Glass, J. I., Hanson, A. D., Henry, C. S. & de Crecy-Lagard, V., 30 Awst 2022, Yn: mBio. e0163022.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2021
- Cyhoeddwyd
Structural and biochemical insights into CRISPR RNA processing by the Cas5c ribonuclease SMU1763 from Streptococcus mutans
Lemak, S., Serbanescu, M. A., Khusnutdinova, A. N., Ruszkowski, M., Beloglazova, N., Xu, X., Brown, G., Cui, H., Tan, K., Joachimiak, A., Cvitkovitch, D. G., Savchenko, A. & Yakunin, A., Tach 2021, Yn: Journal of Biological Chemistry. 297, 5, 101251.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2020
- Cyhoeddwyd
A microplate screen to estimate metal-binding affinities of metalloproteins
Diep, P., Mahadevan, R. & Yakunin, A. F., 15 Tach 2020, Yn: Analytical biochemistry. 609, t. 113836Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Proteome cold-shock response in the extremely acidophilic archaeon, Cuniculiplasma divulgatum
Bargiela, R., Lanthaler, K., Potter, C., Ferrer, M., Yakunin, A., Paizs, B., Golyshin, P. & Golyshina, O., 19 Mai 2020, Yn: Microorganisms . 8, 5Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
One-pot biocatalytic transformation of adipic acid to 6-aminocaproic acid and 1,6-hexamethylenediamine using carboxylic acid reductases and transaminases
Fedorchuk, T. P., Khusnutdinova, A. N., Evdokimova, E., Flick, R., Di Leo, R., Stogios, P. J., Savchenko, A. & Yakunin, A., 15 Ion 2020, Yn: Journal of the American Chemical Society. 142, 2, t. 1038-1048 11 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2019
- Cyhoeddwyd
Site-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus
Fedorchuk, T. P., Khusnutdinova, A. N., Flick, R. & Yakunin, A., 10 Medi 2019, Yn: Journal of Biotechnology. 303, t. 72-79Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Prenylated FMN: biosynthesis, purification, and Fdc1 activation
Khusnutdinova, A. N., Xiao, J., Wang, P-H., Batyrova, K., Flick, R., Edwards, E. & Yakunin, A., 2019, New Approaches for Flavin Catalysis. Palfey, B. A. (gol.). Elsevier, Cyfrol 620. t. 469-488 (Methods in Enzymology).Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid
- 2018
- Cyhoeddwyd
Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters
Hajighasemi, M., Tchigvintsev, A., Nocek, B., Flick, R., Popovic, A., Hai, T., Khusnutdinova, A. N., Brown, G., Xu, X., Cui, H., Anstett, J., Chernikova, T., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Golyshina, O., Savchenko, A., Golyshin, P., Edwards, E. A. & Yakunin, A. F., 6 Tach 2018, Yn: Environmental Science and Technology. 52, 21, t. 12388-12401Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases
Nocek, B. P., Khusnutdinova, A. N., Ruszkowski, M., Flick, R., Burda, M., Batyrova, K., Brown, G., Mucha, A., Joachimiak, A., Berlicki, L. & Yakunin, A. F., 2 Tach 2018, Yn: ACS Catalysis. 8, 11, t. 10746-10760Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Heavy metal removal by bioaccumulation using genetically engineered microorganisms
Diep, P., Mahadevan, R. & Yakunin, A., 29 Hyd 2018, Yn: Frontiers in Bioengineering and Biotechnology. 6, 157.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Engineering a short, aldolase based pathway for (R)-1,3-butanediol production in Escherichia coli
Nemr, K., Muller, J., Joo, J. C., Gawand, P., Cjoudhary, R., Mendonca, B., Lu, S., Yu, X., Yakunin, A. & Mahadevan, R., 1 Gorff 2018, Yn: Metabolic Engineering. 48, t. 13-24Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Biosynthesis and activity of prenylated FMN cofactors
Wang, P-H., Khusnutdinova, A. N., Luo, F., Xiao, J., Nemr, K., Flick, R., Brown, G., Mahadevan, R., Edwards, E. & Yakunin, A., 17 Mai 2018, Yn: Cell Chemical Biology. 25, 5, t. 560-570Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Relationships between Substrate Promiscuity and Chiral Selectivity of Esterases from Phylogenetically and Environmentally Diverse Microorganisms
Coscolín, C., Martínez-Martínez, M., Chow, J., Bargiela, R., García-Moyano, A., Bjerga, G. E. K., Bollinger, A., Stokke, R., Steen, I. H., Golyshina, O., Yakimov, M. M., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P. & Ferrer, M., 5 Ion 2018, Yn: Catalysts. 8, 1, 10.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Determinants and prediction of esterase substrate promiscuity patterns
Martínez-Martínez, M., Coscolín, C., Santiago, G., Chow, J., Stogios, P. J., Bargiela, R., Gertler, C., Navarro-Fernández, J., Bollinger, A., Thies, S., Méndez-García, C., Popovic, A., Brown, G., Chernikova, T., García-Moyano, A., Bjerga, G. E. K., Perez-Garcia, P., Hai, T., del Pozo, M. V., Stokke, R., Steen, I. H., Cui, H., Xu, X., Nocek, B., Alcaide, M., Disasto, M., Mesa, V., Pelaez, A. I., Sanchez, J., Buchholz, P. C. F., Pleiss, J., Fernández-Guerra, A., Glockner, F. O., Golyshina, O., Yakimov, M. M., Savchenko, A., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P., Guallar, V. & Ferrer, M., 2018, Yn: ACS Chemical Biology. 13, 1, t. 225-234Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2017
- Cyhoeddwyd
Metabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YT
Golyshina, O., Hai, T., Reva, O. N., Lemak, S., Yakunin, A. F., Goesmann, A., Nechitaylo, T. Y., LaCono, V., Smedile, F., Slesarev, A., Rojo, D., Barbas, C., Ferrer, M., Yakimov, M. M. & Golyshin, P., 16 Meh 2017, Yn: Scientific Reports. 7, 3682.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- Cyhoeddwyd
Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families
Popovic, A., Hai, T., Tchigvintsev, A., Hajighasemi, M., Nocek, B., Khusnutdinova, A. N., Brown, G., Glinos, J., Flick, R., Skarina, T., Chernikova, T., Yim, V., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Ferrer, M., Golyshina, O., Savchenko, A., Golyshin, P. & Yakunin, A. F., Maw 2017, Yn: Scientific Reports. 7, 44103, 44103.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid
Joo, J. C., Khusnutdinova, A. N., Flick, R., Kim, T., Bornscheuer, U. T., Yakunin, A. F. & Mahadevan, R., 1 Chwef 2017, Yn: Chemical Science. 8, 2, t. 1406-1413Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Schneider, C., Oellerich, T., Baldauf, H-M., Schwarz, S-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W. E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M-L., Yakunin, A. F., Geisslinger, G., Stroebel, P., Ferreiros, N., Serve, H., Keppler, O. T. & Cinatl, J. J., Chwef 2017, Yn: Nature Medicine. 23, 2, t. 250-255Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
- 2016
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A family of metal-dependent phosphatases implicated in metabolite damage-control
Huang, L., Khusnutdinova, A., Nocek, B., Brown, G., Xu, X., Cui, H., Petit, P., Flick, R., Zallot, R., Balmant, K., Ziemak, M. J., Shanklin, J., de Crecy-Lagard, V., Fiehn, O., Gregory, J. F. . III., Joachimiak, A., Savchenko, A., Yakunin, A. F. & Hanson, A. D., Awst 2016, Yn: Nature Chemical Biology. 12, 8, t. 621-627Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid