Application of SNPs for population genetics of nonmodel organisms: new opportunities and challenges
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Molecular Ecology Resources, Cyfrol 11, Rhif S1, 03.2011, t. 123-136.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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TY - JOUR
T1 - Application of SNPs for population genetics of nonmodel organisms: new opportunities and challenges
AU - Helyar, Sarah
AU - Hemmer-Hansen, J.
AU - Bekkevold, Dorte
AU - Taylor, Martin I.
AU - Ogden, Rob
AU - Limborg, Morten T
AU - Cariani, Alessia
AU - Maes, Gregory E.
AU - Diopere, Eveine
AU - Carvalho, Gary
AU - Nielsen, Anders
PY - 2011/3
Y1 - 2011/3
N2 - Recent improvements in the speed, cost and accuracy of next generation sequencing are revolutionizing the discovery of single nucleotide polymorphisms (SNPs). SNPs are increasingly being used as an addition to the molecular ecology toolkit in nonmodel organisms, but their efficient use remains challenging. Here, we discuss common issues when employing SNP markers, including the high numbers of markers typically employed, the effects of ascertainment bias and the inclusion of nonneutral loci in a marker panel. We provide a critique of considerations specifically associated with the application and population genetic analysis of SNPs in nonmodel taxa, focusing specifically on some of the most commonly applied methods
AB - Recent improvements in the speed, cost and accuracy of next generation sequencing are revolutionizing the discovery of single nucleotide polymorphisms (SNPs). SNPs are increasingly being used as an addition to the molecular ecology toolkit in nonmodel organisms, but their efficient use remains challenging. Here, we discuss common issues when employing SNP markers, including the high numbers of markers typically employed, the effects of ascertainment bias and the inclusion of nonneutral loci in a marker panel. We provide a critique of considerations specifically associated with the application and population genetic analysis of SNPs in nonmodel taxa, focusing specifically on some of the most commonly applied methods
KW - ascertainment bias
KW - nonneutral loci
KW - outlier detection
KW - population genomics
KW - population structure
KW - software
U2 - 10.1111/j.1755-0998.2010.02943.x
DO - 10.1111/j.1755-0998.2010.02943.x
M3 - Article
VL - 11
SP - 123
EP - 136
JO - Molecular Ecology Resources
JF - Molecular Ecology Resources
SN - 1755-098X
IS - S1
ER -