Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis. / Hughes, Dyfrig A.; Culeddu, Giovanna; Plumpton, Catrin O. et al.
Yn: Ophthalmology, Cyfrol 126, Rhif 3, 03.2019, t. 415-424.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Hughes, DA, Culeddu, G, Plumpton, CO, Wood, E, Dick, AD, Jones, AP, McKay, A, Williamson, PR, Compeyrot Lacassagne, S, Hardwick, B, Hickey, H, Woo, P, Beresford, MW & Ramanan, AV 2019, 'Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis', Ophthalmology, cyfrol. 126, rhif 3, tt. 415-424. https://doi.org/10.1016/j.ophtha.2018.09.043

APA

Hughes, D. A., Culeddu, G., Plumpton, C. O., Wood, E., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot Lacassagne, S., Hardwick, B., Hickey, H., Woo, P., Beresford, M. W., & Ramanan, A. V. (2019). Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis. Ophthalmology, 126(3), 415-424. https://doi.org/10.1016/j.ophtha.2018.09.043

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Hughes DA, Culeddu G, Plumpton CO, Wood E, Dick AD, Jones AP et al. Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis. Ophthalmology. 2019 Maw;126(3):415-424. Epub 2018 Hyd 16. doi: 10.1016/j.ophtha.2018.09.043

Author

RIS

TY - JOUR

T1 - Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis

AU - Hughes, Dyfrig A.

AU - Culeddu, Giovanna

AU - Plumpton, Catrin O.

AU - Wood, Eifiona

AU - Dick, Andrew D.

AU - Jones, Ashley P.

AU - McKay, Andrew

AU - Williamson, Paula R.

AU - Compeyrot Lacassagne, Sandrine

AU - Hardwick, Ben

AU - Hickey, Helen

AU - Woo, Patricia

AU - Beresford, Michael W.

AU - Ramanan, Athimalaipet V.

N1 - This project was funded by the National Institute for Health Research Health Technology Assessment Programme (project 09/51/01) and Arthritis Research UK (grant reference 19612).

PY - 2019/3

Y1 - 2019/3

N2 - Purpose: To investigate the cost-effectiveness of adalimumab in combination with methotrexate, compared with methotrexate alone, for the management of uveitis associated with Juvenile Idiopathic Arthritis (JIA-U).Design: A cost-utility analysis based on a clinical trial and decision analytic model.Participants: Children and adolescents aged 2 to 18 years with persistently active JIA-U, despite optimized methotrexate treatment for at least 12 weeks.Methods: The SYCAMORE trial [ISRCTN10065623] of methotrexate (up to 25mg per week) with or without fortnightly administered adalimumab (20mg or 40mg, according to body weight) provided data on resource use (based on patient self-report and electronic records) and health utilities (from the Health Utilities Index questionnaire). Surgical event rates and long-term outcomes were based on data from a 10-year longitudinal cohort. A Markov model was used to extrapolate the effects of treatment based on visual impairment.Main outcome measures: Medical costs to the National Health Service in the UK, utility of defined health states, quality-adjusted life years (QALY), and incremental cost per QALY.Results: Adalimumab in combination with methotrexate resulted in additional costs of £39,316 with a 0.30 QALY gain compared with methotrexate alone, resulting in an incremental cost-effectiveness ratio of £129,025 per QALY gained. The probability of cost-effectiveness at a threshold of £30,000 per QALY was less than 1%. Based on a threshold analysis, a price reduction of 84% would be necessary for adalimumab to be cost-effective.Conclusions: Adalimumab is clinically effective in JIA-U, however its cost-effectiveness is not demonstrated compared with methotrexate alone in the UK setting.

AB - Purpose: To investigate the cost-effectiveness of adalimumab in combination with methotrexate, compared with methotrexate alone, for the management of uveitis associated with Juvenile Idiopathic Arthritis (JIA-U).Design: A cost-utility analysis based on a clinical trial and decision analytic model.Participants: Children and adolescents aged 2 to 18 years with persistently active JIA-U, despite optimized methotrexate treatment for at least 12 weeks.Methods: The SYCAMORE trial [ISRCTN10065623] of methotrexate (up to 25mg per week) with or without fortnightly administered adalimumab (20mg or 40mg, according to body weight) provided data on resource use (based on patient self-report and electronic records) and health utilities (from the Health Utilities Index questionnaire). Surgical event rates and long-term outcomes were based on data from a 10-year longitudinal cohort. A Markov model was used to extrapolate the effects of treatment based on visual impairment.Main outcome measures: Medical costs to the National Health Service in the UK, utility of defined health states, quality-adjusted life years (QALY), and incremental cost per QALY.Results: Adalimumab in combination with methotrexate resulted in additional costs of £39,316 with a 0.30 QALY gain compared with methotrexate alone, resulting in an incremental cost-effectiveness ratio of £129,025 per QALY gained. The probability of cost-effectiveness at a threshold of £30,000 per QALY was less than 1%. Based on a threshold analysis, a price reduction of 84% would be necessary for adalimumab to be cost-effective.Conclusions: Adalimumab is clinically effective in JIA-U, however its cost-effectiveness is not demonstrated compared with methotrexate alone in the UK setting.

KW - Anti-TNF

KW - Juvenile Idiopathic Arthritis

KW - uveitis

KW - Cost-effectiveness

KW - Economic Evaluation

U2 - 10.1016/j.ophtha.2018.09.043

DO - 10.1016/j.ophtha.2018.09.043

M3 - Article

VL - 126

SP - 415

EP - 424

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 3

ER -