N-carbamate protected amino acid derived guanidine organocatalysts
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- 2021 N-carbamate protected amino acid derived guanidine organocatalysts
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Dangosydd eitem ddigidol (DOI)
We report the preparation of a range of N-protected amino acid derived guanidine organocatalysts and their application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 26%. Whilst these catalysts gave poor ees, the structural variation together with the X-ray crystallographic study of the intra- and intermolecular hydrogen bonding reported suggest that the C2-symmetric catalysts are lead compounds for the further development of this methodology.
Allweddeiriau
| Iaith wreiddiol | Saesneg |
|---|---|
| Rhif yr erthygl | 132093 |
| Cyfnodolyn | Tetrahedron |
| Cyfrol | 89 |
| Dyddiad ar-lein cynnar | 2 Ebr 2021 |
| Dynodwyr Gwrthrych Digidol (DOIs) | |
| Statws | Cyhoeddwyd - 4 Meh 2021 |
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