N-carbamate protected amino acid derived guanidine organocatalysts

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  • 2021 N-carbamate protected amino acid derived guanidine organocatalysts

    Llawysgrif awdur wedi’i dderbyn, 4.78 MB, dogfen-PDF

    Embargo yn dod i ben: 2/04/22

    Trwydded: CC BY-NC-ND Dangos trwydded

Dangosydd eitem ddigidol (DOI)

  • Zahraa S. Al-Taie
    Al-Nahrain University, Baghdad, Iraq
  • Joseph M. Anderson
    Bangor University
  • Laura Bischoff
    Bangor University
  • Jeppe Christensen
    Diamond Light Source, Didcot
  • Simon J. Coles
    University of Southampton
  • Richard Froom
  • Mari E. Gibbard
    Bangor University
  • Leigh F. Jones
    University of Wolverhampton
  • Frank F. J. de Kleijne
    Bangor University
  • Paddy Murphy
  • Emma Thompson
    Bangor University
We report the preparation of a range of N-protected amino acid derived guanidine organocatalysts and their application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 26%. Whilst these catalysts gave poor ees, the structural variation together with the X-ray crystallographic study of the intra- and intermolecular hydrogen bonding reported suggest that the C2-symmetric catalysts are lead compounds for the further development of this methodology.

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