N-carbamate protected amino acid derived guanidine organocatalysts
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- 2021 N-carbamate protected amino acid derived guanidine organocatalysts
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DOI
We report the preparation of a range of N-protected amino acid derived guanidine organocatalysts and their application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 26%. Whilst these catalysts gave poor ees, the structural variation together with the X-ray crystallographic study of the intra- and intermolecular hydrogen bonding reported suggest that the C2-symmetric catalysts are lead compounds for the further development of this methodology.
Keywords
- Amino acids, Guanidines, H-bonded extended networks, Organocatalysis
| Original language | English |
|---|---|
| Article number | 132093 |
| Journal | Tetrahedron |
| Volume | 89 |
| Early online date | 2 Apr 2021 |
| DOIs | |
| Publication status | Published - 4 Jun 2021 |
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